肥大细胞活化可能导致COVID-19衰弱患者的不良健康转化

数据集获取（Figshare）

• 源站标题：Mast cell activation may contribute to adverse health transitions in COVID-19 patients with frailty
• DOI：10.6084/m9.figshare.24006797.v2
• 发布日期：2023-08-30
• 文件数：2 个
• 文件总体积：468.11 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/Mast_cell_activation_may_contribute_to_adverse_health_transitions_in_COVID-19_patients_with_frailty/24006797

命令行下载

curl -L -o "temi_a_2251589_sm9283.xlsx" "https://ndownloader.figshare.com/files/42209734"
curl -L -o "temi_a_2251589_sm9221.pdf" "https://ndownloader.figshare.com/files/42209737"

文件清单

• temi_a_2251589_sm9283.xlsx（13.46 KB）
• temi_a_2251589_sm9221.pdf（454.64 KB）

文件总体积 468.11 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

A prominent aspect of the post-coronavirus disease-2019 (post-COVID-19) era is long-COVID. Therefore, precise patient classification and exploration of the corresponding factors affecting long-COVID are crucial for tailored treatment strategies. Frailty is a common age-related clinical syndrome characterized by deteriorated physiological functions of multiple organ systems, which increases susceptibility to stressors. Herein, we performed an inclusion and exclusion analysis (definite COVID-19 infection diagnosis, clear underlying disease information, ≥60 years old, and repeated sampling of clinical cases) of 10,613 blood samples and identified frailty cases for further investigation. RNA-Seq data were used for differential gene expression and functional and pathway analyses. The results revealed that patients with frailty were more prone to poor health conversions and more sequelae, and the blood transcriptome had obvious disturbances in pathways associated with immune regulation, metabolism, and stress response. These adverse health transitions were significantly associated with mast cell activation. Additionally, NCAPG, MCM10, and CDC25C were identified as hub genes in the peripheral blood differential gene cluster, which could be used as diagnostic markers of poor health conversion. Our results indicate that healthcare measures should be prioritized to mitigate adverse health outcomes in this vulnerable patient group, COVID-19 patients with frailty, in post-COVID era.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.24006797.v2（source: https://tandf.figshare.com/articles/dataset/Mast_cell_activation_may_contribute_to_adverse_health_transitions_in_COVID-19_patients_with_frailty/24006797）。