精神分裂症和双相情感障碍的外周与中枢先天免疫改变：NK细胞、单核细胞和巨噬细胞的系统综述

数据集获取（Figshare）

• 源站标题：Peripheral and central innate immune alterations in schizophrenia and bipolar disorder: a systematic review of NK cells, monocytes and macrophages
• DOI：10.6084/m9.figshare.30508966.v1
• 发布日期：2025-11-02
• 文件数：2 个
• 文件总体积：1.40 MB
• 源站页面：https://tandf.figshare.com/articles/dataset/Peripheral_and_central_innate_immune_alterations_in_schizophrenia_and_bipolar_disorder_a_systematic_review_of_NK_cells_monocytes_and_macrophages/30508966

命令行下载

curl -L -o "iwbp_a_2570169_sm8171.docx" "https://ndownloader.figshare.com/files/59235572"
curl -L -o "iwbp_a_2570169_sm8170.docx" "https://ndownloader.figshare.com/files/59235575"

文件清单

• iwbp_a_2570169_sm8171.docx（77.53 KB）
• iwbp_a_2570169_sm8170.docx（1.32 MB）

文件总体积 1.40 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Innate immune dysfunction is implicated in schizophrenia (SZ) and bipolar disorder (BD). Alterations in natural killer (NK) cells, monocytes and macrophages occur in both disorders across peripheral and central compartments. This systematic review synthesises current evidence by clinical stage and illness phase.
Following PRISMA guidelines, PubMed, Scopus and PsycINFO were searched to May 2025. Eligible studies reported peripheral blood, cerebrospinal fluid (CSF) or post-mortem brain findings.
Eighty-one studies met inclusion criteria. In SZ, peripheral data showed altered NK cell subsets and monocyte abnormalities, including elevated counts and inflammatory ratios, particularly in early or acute stages. CSF studies found increased monocyte chemoattractants, and post-mortem analyses revealed macrophage upregulation in frontal and temporal cortices. In BD, NK cell results were limited and inconsistent. Monocyte activation was most evident during symptomatic phases, particularly mania. CSF analyses detected increased monocyte- and macrophage-associated proteins, while post-mortem findings indicated microglial activation in selected cortical and subcortical regions, less consistently than in SZ.
Innate immune alterations in SZ and BD partly overlap yet remain disorder- and state-specific. Central compartments and NK cells are underexplored. Stratification by stage and phase may improve interpretability and guide longitudinal, multimodal, cell-specific research for precision immunopsychiatry.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.30508966.v1（source: https://tandf.figshare.com/articles/dataset/Peripheral_and_central_innate_immune_alterations_in_schizophrenia_and_bipolar_disorder_a_systematic_review_of_NK_cells_monocytes_and_macrophages/30508966）。