年轻镰状细胞病患者羟基脲依从性高于儿童和青少年数据集
113名镰状细胞病患者羟基脲依从性的回顾性数据，比较儿童、青少年与年轻成人的依从性差异及与医疗利用的关系。
基本信息
资源简介
年轻镰状细胞病患者羟基脲依从性高于儿童和青少年数据集
【数据集背景】
本数据集源站标题为《Higher hydroxyurea adherence among young adults with sickle cell disease compared to children and adolescents》。配套论文《Higher hydroxyurea adherence among young adults with sickle cell disease compared to children and adolescents》发表于 Annals of Medicine（2022），DOI：10.1080/07853890.2022.2044509。项目资助方：This project was supported by grant [K23HL150232, P I: Badawy] from the National Heart, Lung, and Blood Institute of the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the National Institutes of Health.。源站首次发布：2022-03-02。
【数据内容】
源站原始描述：Sickle cell disease (SCD) results in severe complications, such as anaemia and pain episodes. Hydroxyurea (HU) is efficacious in SCD, yet adherence remains low. To assess the relationship of HU adherence to health care utilization and patients’ characteristics. This is a 5-year retrospective chart review. Patients’ demographics and medical history were collected from the electronic medical record (EMR). HU adherence was evaluated using foetal haemoglobin “HbF%”, mean corpuscular volume “MCV”, an…
【数据结构与技术规格】
文件数 2 个，合计 39.17 KB。iann_a_2044509_sm5767.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，18.43 KB。iann_a_2044509_sm5764.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，20.74 KB。数据集 DOI：10.6084/m9.figshare.19291342.v1。
【主题与分类】
源站学科分类：Medicine、Cell Biology、Sociology、Biological Sciences not elsewhere classified、Science Policy、Infectious Diseases。主题标签：Sickle cell、adherence、compliance、hydroxyurea、hydroxycarbamide、chronic pain、health care utilization、AYA、adolescents and young adults、haemoglobinopathy。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://tandf.figshare.com/articles/dataset/Higher_hydroxyurea_adherence_among_young_adults_with_sickle_cell_disease_compared_to_children_and_adolescents/19291342
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Higher hydroxyurea adherence among young adults with sickle cell disease compared to children and adolescents. Taylor & Francis. Reddy, Paavani S.; Cai, Stephanie W.; Barrera, Leonardo; King, Kathryn; Badawy, Sherif M
【使用注意】
· 源站最后修改于 2026-01-27，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：Higher hydroxyurea adherence among young adults with sickle cell disease compared to children and adolescents
- DOI：10.6084/m9.figshare.19291342.v1
- 发布日期：2022-03-02
- 文件数：2 个
- 文件总体积：39.17 KB
- 源站页面：https://tandf.figshare.com/articles/dataset/Higher_hydroxyurea_adherence_among_young_adults_with_sickle_cell_disease_compared_to_children_and_adolescents/19291342
命令行下载
curl -L -o "iann_a_2044509_sm5767.docx" "https://ndownloader.figshare.com/files/34258507"
curl -L -o "iann_a_2044509_sm5764.docx" "https://ndownloader.figshare.com/files/34258510"
文件清单
iann_a_2044509_sm5767.docx（18.43 KB）iann_a_2044509_sm5764.docx（20.74 KB）
文件总体积 39.17 KB（源站 API 实测）。
数据说明
Sickle cell disease (SCD) results in severe complications, such as anaemia and pain episodes. Hydroxyurea (HU) is efficacious in SCD, yet adherence remains low.
To assess the relationship of HU adherence to health care utilization and patients’ characteristics.
This is a 5-year retrospective chart review. Patients’ demographics and medical history were collected from the electronic medical record (EMR). HU adherence was evaluated using foetal haemoglobin “HbF%”, mean corpuscular volume “MCV”, and absolute neutrophil count “ANC”. Age groups included children (A total of 113 SCD patients on HU were included (median age 14 years, IQR 10–20; 50% female; 88% HbSS). Young adults had significantly higher HU adherence compared to adolescents and children, including higher median HbF% (24.2 vs. 12.4 vs. 8.6, p = .003), MCV (fl) (106.4 vs. 96.2 vs. 95.4, p = .01) and lower ANC (103/ml) (3.25 vs. 4.9 vs. 4.2, p = .01), respectively. Patients with chronic pain had lower HU adherence (HbF% 15.3 vs. 10.7, p = .04; ANC 3.6 vs. 6.3, p = .002; MCV 102.3 vs. 93.1, p = .1). Patients with higher HbF or MCV and lower ANC had significantly less frequent emergency room visits (rs=–0.26, p = .01; rs=–0.23, p = .01; rs=0.24, p = .01) and hospitalizations (rs=–0.27, p = .01; rs=–0.31, p = .01; rs=0.21, p = .02) as well as shorter length of stays (rs=–0.27, p = .0045; rs=–.34, p = 0.004; rs=0.23, p = .02), respectively. Similar trends in HU adherence and health care utilization were seen in subgroup analysis of only HbSS patients. There was no significant association of HU adherence to patients’ sex, socio-economic status, distance from hospital, and HU duration.
Young adults with SCD had significantly higher HU adherence compared to children and adolescents. Patients with lower HU adherence and/or chronic pain had increased health care utilization. Future studies examining barriers to adherence and evaluating interventions to optimize HU adherence in SCD are warranted.KEY MESSAGES
Young adults with SCD had significantly higher HU adherence, as reflected in their laboratory markers, compared to children and adolescents.
Patients with higher HU adherence and/or those without chronic pai
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.6084/m9.figshare.19291342.v1（source: https://tandf.figshare.com/articles/dataset/Higher_hydroxyurea_adherence_among_young_adults_with_sickle_cell_disease_compared_to_children_and_adolescents/19291342）。
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