巴德-毕德氏综合征蛋白缺失导致主要神经元突触异常

资源简介

巴德-毕德氏综合征蛋白缺失导致主要神经元突触异常

【数据集背景】

本数据集源站标题为《Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons》。配套论文《Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons》发表于 PLOS Biology（2019），DOI：10.1371/journal.pbio.3000414。源站首次发布：2019-09-03。

【数据内容】

源站原始描述：Bardet-Biedl syndrome (BBS), a ciliopathy, is a rare genetic condition characterised by retinal degeneration, obesity, kidney failure, and cognitive impairment. In spite of progress made in our general understanding of BBS aetiology, the molecular and cellular mechanisms underlying cognitive impairment in BBS remain elusive. Here, we report that the loss of BBS proteins causes synaptic dysfunction in principal neurons, providing a possible explanation for the cognitive impairment phenotype obser…

【数据结构与技术规格】

文件数 13 个，合计 36.23 MB。pbio.3000414.s001.tif：image/tiff，777.25 KB。pbio.3000414.s003.tif：image/tiff，827.96 KB。数据集 DOI：10.1371/journal.pbio.3000414。

【主题与分类】

源站学科分类：Medicine、Cell Biology、Genetics、Neuroscience、Hematology、Computational Biology。主题标签：destabilise spine architecture、BBS proteins causes synaptic dysfunction、neurons Bardet-Biedl syndrome、spine deficiency correlates、Bbs mouse models、dendritic spine homeostasis、dendritic spines、spine membrane receptor、Bardet-Biedl syndrome proteins causes synaptic aberrations、impairment。

【适用方向】

源站学科分类标注为 Medicine、Cell Biology、Genetics、Neuroscience、Hematology、Computational Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Loss_of_Bardet-Biedl_syndrome_proteins_causes_synaptic_aberrations_in_principal_neurons/9764381

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Haq, Naila; Schmidt-Hieber, Christoph; Sialana, Fernando J.; Ciani, Lorenza; Heller, Janosch P.; Stewart, Michelle; et al. (2019). Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons. PLOS Biology. Dataset

【使用注意】

· 源站最后修改于 2023-06-03，引用时请注意版本时效。