原发性维生素D靶向基因：维生素D3补充可能益处的分类

数据集获取（Figshare）

• 源站标题：Primary Vitamin D Target Genes Allow a Categorization of Possible Benefits of Vitamin D₃ Supplementation
• DOI：10.1371/journal.pone.0071042
• 发布日期：2013-07-29
• 文件数：2 个
• 文件总体积：4.38 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Primary_Vitamin_D_Target_Genes_Allow_a_Categorization_of_Possible_Benefits_of_Vitamin_D_3_Supplementation/758248

命令行下载

curl -L -o "File_S1.pdf" "https://ndownloader.figshare.com/files/1135058"
curl -L -o "File_S2.xlsx" "https://ndownloader.figshare.com/files/1135059"

文件清单

• File_S1.pdf（4.33 MB）
• File_S2.xlsx（58.77 KB）

文件总体积 4.38 MB（源站 API 实测）。

数据说明

Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic individuals of the VitDmet study, a 5-month high dose vitamin D3 intervention trial during Finnish winter, for their changes in serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations and the expression of primary vitamin D target genes in peripheral blood mononuclear cells and adipose tissue. A negative correlation between serum concentrations of parathyroid hormone and 25(OH)D3 suggested an overall normal physiological vitamin D response among the participants. The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues. However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D3 concentrations. Interestingly, this categorization allows unmasking a negative correlation between changes in serum concentrations of 25(OH)D3 and the inflammation marker interleukin 6. We propose the genes CD14 and THBD as transcriptomic biomarkers, from which the effects of a vitamin D3 supplementation can be evaluated. These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D3 supplementation, and others who do not.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0071042（source: https://plos.figshare.com/articles/dataset/Primary_Vitamin_D_Target_Genes_Allow_a_Categorization_of_Possible_Benefits_of_Vitamin_D_3_Supplementation/758248）。