HIF1α调控环路连接嗜铬细胞瘤中的缺氧与线粒体信号

资源简介

HIF1α调控环路连接嗜铬细胞瘤中的缺氧与线粒体信号

【数据集背景】

本数据集源站标题为《A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas》。配套论文《A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas》发表于 PLoS Genetics（2005），DOI：10.1371/journal.pgen.0010008。源站首次发布：2013-01-20。

【数据内容】

源站原始描述：Pheochromocytomas are neural crest–derived tumors that arise from inherited or sporadic mutations in at least six independent genes. The proteins encoded by these multiple genes regulate distinct functions. We show here a functional link between tumors with VHL mutations and those with disruption of the genes encoding for succinate dehydrogenase (SDH) subunits B (SDHB) and D (SDHD). A transcription profile of reduced oxidoreductase is detected in all three of these tumor types, together with an…

【数据结构与技术规格】

文件数 5 个，合计 549.99 KB。Dataset_S1.pdf：application/pdf，13.85 KB。Dataset_S2.pdf：application/pdf，140.98 KB。Dataset_S3.pdf：application/pdf，28.54 KB。数据集 DOI：10.1371/journal.pgen.0010008。

【主题与分类】

源站学科分类：Chemistry、Genetics、Cell Biology、Molecular Biology、Cancer、Biological Sciences。主题标签：links、hypoxia、mitochondrial、signals、pheochromocytomas。

【适用方向】

源站学科分类标注为 Chemistry、Genetics、Cell Biology、Molecular Biology、Cancer、Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/A_HIF1_Regulatory_Loop_Links_Hypoxia_and_Mitochondrial_Signals_in_Pheochromocytomas/153185

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：L. M Dahia, Patricia; N Ross, Ken; E Wright, Matthew; Y Hayashida, César; Santagata, Sandro; Barontini, Marta; et al. (2016). A HIF1α Regulatory Loop Links Hypoxia and Mitochondrial Signals in Pheochromocytomas. PLOS Genetics. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。