糖尿病骨质减少症中β-连环蛋白信号通路减弱部分由sFRP-4基因表观遗传去抑制诱导

资源简介

糖尿病骨质减少症中β-连环蛋白信号通路减弱部分由sFRP-4基因表观遗传去抑制诱导

【数据集背景】

本数据集源站标题为《Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene》。配套论文《Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene》发表于 PLoS ONE（2014），DOI：10.1371/journal.pone.0102797。源站首次发布：2014-07-18。

【数据内容】

源站原始描述：In diabetics, methylglyoxal (MG), a glucose-derived metabolite, plays a noxious role by inducing oxidative stress, which causes and exacerbates a series of complications including low-turnover osteoporosis. In the present study, while MG treatment of mouse bone marrow stroma-derived ST2 cells rapidly suppressed the expression of osteotrophic Wnt-targeted genes, including that of osteoprotegerin (OPG, a decoy receptor of the receptor activator of NF-kappaB ligand (RANKL)), it significantly enhanc…

【数据结构与技术规格】

文件数 2 个，合计 1.50 MB。Figure_S1.tif：image/tiff，652.07 KB。Figure_S2.tif：image/tiff，852.51 KB。数据集 DOI：10.1371/journal.pone.0102797。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：anatomy、biological tissue、Connective tissue、bone、Musculoskeletal system、cell biology、Cell processes、Cellular stress responses、Signal transduction、cell signaling。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Diabetic_Osteopenia_by_Decreased_946_Catenin_Signaling_Is_Partly_Induced_by_Epigenetic_Derepression_of_sFRP_4_Gene_/1111011

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Mori, Kiyoshi; Kitazawa, Riko; Kondo, Takeshi; Mori, Michiko; Hamada, Yasuhiro; Nishida, Michiru; et al. (2016). Diabetic Osteopenia by Decreased β-Catenin Signaling Is Partly Induced by Epigenetic Derepression of sFRP-4 Gene. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-02，引用时请注意版本时效。