泰国使用串联质谱进行新生儿先天性代谢缺陷筛查的经济评估

数据集获取（Figshare）

• 源站标题：An Economic Evaluation of Neonatal Screening for Inborn Errors of Metabolism Using Tandem Mass Spectrometry in Thailand
• DOI：10.1371/journal.pone.0134782
• 发布日期：2015-08-10
• 文件数：4 个
• 文件总体积：68.67 KB
• 源站页面：https://plos.figshare.com/articles/dataset/_An_Economic_Evaluation_of_Neonatal_Screening_for_Inborn_Errors_of_Metabolism_Using_Tandem_Mass_Spectrometry_in_Thailand_/1507309

命令行下载

curl -L -o "S1_Table.docx" "https://ndownloader.figshare.com/files/2207564"
curl -L -o "S2_Table.docx" "https://ndownloader.figshare.com/files/2207565"
curl -L -o "S3_Table.docx" "https://ndownloader.figshare.com/files/2207566"
curl -L -o "S1_Search_Strategy.docx" "https://ndownloader.figshare.com/files/2207567"

文件清单

• S1_Table.docx（22.88 KB）
• S2_Table.docx（13.05 KB）
• S3_Table.docx（16.39 KB）
• S1_Search_Strategy.docx（16.34 KB）

文件总体积 68.67 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Inborn errors of metabolism (IEM) are a rare group of genetic diseases which can lead to several serious long-term complications in newborns. In order to address these issues as early as possible, a process called tandem mass spectrometry (MS/MS) can be used as it allows for rapid and simultaneous detection of the diseases. This analysis was performed to determine whether newborn screening by MS/MS is cost-effective in Thailand.
Method
A cost-utility analysis comprising a decision-tree and Markov model was used to estimate the cost in Thai baht (THB) and health outcomes in life-years (LYs) and quality-adjusted life year (QALYs) presented as an incremental cost-effectiveness ratio (ICER). The results were also adjusted to international dollars (I$) using purchasing power parities (PPP) (1 I$ = 17.79 THB for the year 2013). The comparisons were between 1) an expanded neonatal screening programme using MS/MS screening for six prioritised diseases: phenylketonuria (PKU); isovaleric acidemia (IVA); methylmalonic acidemia (MMA); propionic acidemia (PA); maple syrup urine disease (MSUD); and multiple carboxylase deficiency (MCD); and 2) the current practice that is existing PKU screening. A comparison of the outcome and cost of treatment before and after clinical presentations were also analysed to illustrate the potential benefit of early treatment for affected children. A budget impact analysis was conducted to illustrate the cost of implementing the programme for 10 years.
Results
The ICER of neonatal screening using MS/MS amounted to 1,043,331 THB per QALY gained (58,647 I$ per QALY gained). The potential benefits of early detection compared with late detection yielded significant results for PKU, IVA, MSUD, and MCD patients. The budget impact analysis indicated that the implementation cost of the programme was expected at approximately 2,700 million THB (152 million I$) over 10 years.
Conclusion
At the current ceiling threshold, neonatal screening using MS/MS in the Thai context is not cost-effective. However, the treatment of patients who were detected early for PKU, IVA, MSUD, and MCD, are considered favourable. The budget impact analysis suggests tha

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0134782（source: https://plos.figshare.com/articles/dataset/_An_Economic_Evaluation_of_Neonatal_Screening_for_Inborn_Errors_of_Metabolism_Using_Tandem_Mass_Spectrometry_in_Thailand_/1507309）。