Dicer酶在甲状腺滤泡细胞中缺失导致甲状腺功能减退并伴有肿瘤样改变的迹象

资源简介

Dicer酶在甲状腺滤泡细胞中缺失导致甲状腺功能减退并伴有肿瘤样改变的迹象

【数据集背景】

本数据集源站标题为《Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations》。配套论文《Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0029929。源站首次发布：2012-01-05。

【数据内容】

源站原始描述：Micro-RNAs (miRNAs) are small non-coding RNAs that regulate gene expression, mainly at mRNA post-transcriptional level. Functional maturation of most miRNAs requires processing of the primary transcript by Dicer, an RNaseIII-type enzyme. To date, the importance of miRNA function for normal organogenesis has been demonstrated in several mouse models of tissue-specific Dicer inactivation. However, the role of miRNAs in thyroid development has not yet been addressed. For the present study, we gener…

【数据结构与技术规格】

文件数 4 个，合计 2.75 MB。Figure_S1.tif：image/tiff，1.56 MB。Figure_S2.tif：image/tiff，1.13 MB。Figure_S3.tif：image/tiff，37.24 KB。数据集 DOI：10.1371/journal.pone.0029929。

【主题与分类】

源站学科分类：Chemistry、Physics、Biochemistry、Developmental Biology、Biophysics、Physiology。主题标签：deletion、rnaseiii、enzyme、dicer、thyroid、follicular、cells、causes、hypothyroidism、signs。

【适用方向】

源站学科分类标注为 Chemistry、Physics、Biochemistry、Developmental Biology、Biophysics、Physiology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Deletion_of_the_RNaseIII_Enzyme_Dicer_in_Thyroid_Follicular_Cells_Causes_Hypothyroidism_with_Signs_of_Neoplastic_Alterations/129910

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Rodriguez, Wendy; Jin, Ling; Janssens, Véronique; Pierreux, Christophe; Hick, Anne-Christine; Urizar, Eneko; et al. (2016). Deletion of the RNaseIII Enzyme Dicer in Thyroid Follicular Cells Causes Hypothyroidism with Signs of Neoplastic Alterations. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-30，引用时请注意版本时效。