LYPLAL1基因附近遗传变异与胃旁路术后饥饿感及体重减轻的相关性数据集

数据集获取（Figshare）

• 源站标题：A genetic variant in proximity to the gene <i>LYPLAL1</i> is associated with lower hunger feelings and increased weight loss following Roux-en-Y gastric bypass surgery
• DOI：10.6084/m9.figshare.3382255.v2
• 发布日期：2016-06-17
• 文件数：1 个
• 文件总体积：14.13 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/A_genetic_variant_in_proximity_to_the_gene_i_LYPLAL1_i_is_associated_with_lower_hunger_feelings_and_increased_weight_loss_following_Roux_en_Y_gastric_bypass_surgery/3382255

命令行下载

curl -L -o "igas_a_1166519_sm4936.xlsx" "https://ndownloader.figshare.com/files/5406788"

文件清单

• igas_a_1166519_sm4936.xlsx（14.13 KB）

文件总体积 14.13 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Objective: Bariatric surgery is the most efficient treatment of severe obesity. We investigated to what extent BMI- or waist-hip ratio (WHR)-related genetic variants are associated with excess BMI loss (EBMIL) two years after Roux-en-Y gastric bypass (RYGB) surgery, and elucidated the affected biological pathways.
Methods: Two-hundred fifty-one obese patients (age: 43 ± 10.7, preoperative BMI: 45.1 ± 6.1 kg/m2, 186 women) underwent RYGB surgery and were followed up after two years with regard to BMI. Patients were genotyped for 32 single-nucleotide polymorphisms (SNPs) that were investigated with regard to their impact on response to RYGB and preoperatively measured Three Factor Eating Questionnaire (TFEQ) scores.
Results: Homozygous T carriers of the SNP rs4846567 in proximity to the Lysophospholipase-like 1 (LYPLAL1) gene showed a 7% higher EBMIL compared to wild-type and heterozygous carriers (p = 0.031). TT-allele carriers showed furthermore lower scores for Hunger (74%, p p p = 0.017) than GG/GT carriers in the TFEQ. Patients within the lowest quartile of Hunger scores had a 32% greater EBMIL compared to patients in the highest quartile (p Conclusion: The LYPLAL1 genotype is associated with differences in eating behavior and loss of extensive body weight following RYGB surgery. Genotyping and the use of eating behavior-related questionnaires may help to estimate the RYGB-associated therapy success.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.3382255.v2（source: https://tandf.figshare.com/articles/dataset/A_genetic_variant_in_proximity_to_the_gene_i_LYPLAL1_i_is_associated_with_lower_hunger_feelings_and_increased_weight_loss_following_Roux_en_Y_gastric_bypass_surgery/3382255）。