小鼠胚胎干细胞功能分析揭示林奇综合征患者中发现的三种MSH6变异体具有野生型活性

资源简介

小鼠胚胎干细胞功能分析揭示林奇综合征患者中发现的三种MSH6变异体具有野生型活性

【数据集背景】

本数据集源站标题为《Functional Analysis in Mouse Embryonic Stem Cells Reveals Wild-Type Activity for Three Msh6 Variants Found in Suspected Lynch Syndrome Patients》。配套论文《Functional Analysis in Mouse Embryonic Stem Cells Reveals Wild-Type Activity for Three Msh6 Variants Found in Suspected Lynch Syndrome Patients》发表于 PLoS ONE（2013），DOI：10.1371/journal.pone.0074766。源站首次发布：2013-09-10。

【数据内容】

源站原始描述：Lynch syndrome confers an increased risk to various types of cancer, in particular early onset colorectal and endometrial cancer. Mutations in mismatch repair (MMR) genes underlie Lynch syndrome, with the majority of mutations found in MLH1 and MSH2. Mutations in MSH6 have also been found but these do not always cause a clear cancer predisposition phenotype and MSH6-defective tumors often do not show the standard characteristics of MMR deficiency, such as microsatellite instability. In particula…

【数据结构与技术规格】

文件数 2 个，合计 459.44 KB。Figure_S1.pdf：application/pdf，372.28 KB。Figure_S2.pdf：application/pdf，87.16 KB。数据集 DOI：10.1371/journal.pone.0074766。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：embryonic、cells、reveals、wild-type、variants、suspected、lynch、patients。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Functional_Analysis_in_Mouse_Embryonic_Stem_Cells_Reveals_Wild_Type_Activity_for_Three_Msh6_Variants_Found_in_Suspected_Lynch_Syndrome_Patients/796291

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：A. L. Wielders, Eva; Houlleberghs, Hellen; Isik, Gözde; te Riele, Hein (2016). Functional Analysis in Mouse Embryonic Stem Cells Reveals Wild-Type Activity for Three Msh6 Variants Found in Suspected Lynch Syndrome Patients. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。