肠道PPARγ缺失通过Lipocalin-2依赖途径加重小鼠急性感染性结肠炎

资源简介

肠道PPARγ缺失通过Lipocalin-2依赖途径加重小鼠急性感染性结肠炎

【数据集背景】

本数据集源站标题为《Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway》。配套论文《Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway》发表于 PLoS Pathogens（2014），DOI：10.1371/journal.ppat.1003887。源站首次发布：2014-01-23。

【数据内容】

源站原始描述：To be able to colonize its host, invading Salmonella enterica serovar Typhimurium must disrupt and severely affect host-microbiome homeostasis. Here we report that S. Typhimurium induces acute infectious colitis by inhibiting peroxisome proliferator-activated receptor gamma (PPARγ) expression in intestinal epithelial cells. Interestingly, this PPARγ down-regulation by S. Typhimurium is independent of TLR-4 signaling but triggers a marked elevation of host innate immune response genes, including…

【数据结构与技术规格】

文件数 10 个，合计 7.38 MB。Figure_S1.tif：image/tiff，332.82 KB。Figure_S2.tif：image/tiff，350.71 KB。Figure_S3.tif：image/tiff，188.25 KB。数据集 DOI：10.1371/journal.ppat.1003887。

【主题与分类】

源站学科分类：Biological Sciences、Medicine。主题标签：microbiology、Gastroenterology and hepatology、intestinal、aggravates、acute、infectious、colitis、mice。

【适用方向】

源站学科分类标注为 Biological Sciences、Medicine。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Absence_of_Intestinal_PPAR_947_Aggravates_Acute_Infectious_Colitis_in_Mice_through_a_Lipocalin_2_8211_Dependent_Pathway_/910158

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Kundu, Parag; Wei Ling, Teo; Korecka, Agata; Li, Yinghui; D''Arienzo, Rossana; M. Bunte, Ralph; et al. (2016). Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway. PLOS Pathogens. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。