血清尿酸与腹膜透析患者胃肠道出血的关系：倾向性评分分析

数据集获取（Figshare）

• 源站标题：The relationship between serum uric acid and gastrointestinal bleeding in peritoneal dialysis patients: a propensity score analysis
• DOI：10.6084/m9.figshare.27145671.v1
• 发布日期：2024-10-02
• 文件数：3 个
• 文件总体积：55.12 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/The_relationship_between_serum_uric_acid_and_gastrointestinal_bleeding_in_peritoneal_dialysis_patients_a_propensity_score_analysis/27145671

命令行下载

curl -L -o "irnf_a_2407881_sm6245.docx" "https://ndownloader.figshare.com/files/49556209"
curl -L -o "irnf_a_2407881_sm6244.docx" "https://ndownloader.figshare.com/files/49556212"
curl -L -o "irnf_a_2407881_sm6243.docx" "https://ndownloader.figshare.com/files/49556215"

文件清单

• irnf_a_2407881_sm6245.docx（18.59 KB）
• irnf_a_2407881_sm6244.docx（18.69 KB）
• irnf_a_2407881_sm6243.docx（17.85 KB）

文件总体积 55.12 KB（源站 API 实测）。

数据说明

Gastrointestinal bleeding is an important gastrointestinal complication among peritoneal dialysis patients and correlated with a higher risk of mortality. Increased uric acid levels are a significant complication for peritoneal dialysis patients and have been associated with an increased risk of hemorrhagic stroke. The objective of the present study was to investigate the relationship between serum uric acid levels and gastrointestinal bleeding in peritoneal dialysis patients.
A total of 2498 peritoneal dialysis patients were recruited. Based on the optimal uric acid cutoff value, two groups of patients were divided. We constructed a propensity-score-matched population of 1762 patients by matching sex, age, and body mass index. Survival outcomes between the two groups were compared using adjusted Kaplan–Meier curves. We constructed the restricted cubic splines regression to assess the correlation between levels of uric acid and gastrointestinal bleeding. A multivariate Cox proportional hazards regression was performed to test whether higher levels of uric acid are an independent risk factor for gastrointestinal bleeding. We performed a forest plot to show interaction effects in different subgroups.
According to restricted cubic splines regression, uric acid levels were positively correlated with the risk of gastrointestinal bleeding events. After adjusted different confounding factors, patients with high levels of uric acid were prone to experience gastrointestinal bleeding (HR 1.868, 95%CI 1.001–3.486). In subgroups, the interaction between higher levels of uric acid and utilizing proton pump inhibitors was significant (P for interaction = 0.034). Further research found that taking proton pump inhibitors could decrease the risk of gastrointestinal bleeding in peritoneal dialysis patients accompanied high levels of uric acid.
The baseline high levels of uric acid are an independent risk factor for gastrointestinal bleeding in patients undergoing peritoneal dialysis.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.27145671.v1（source: https://tandf.figshare.com/articles/dataset/The_relationship_between_serum_uric_acid_and_gastrointestinal_bleeding_in_peritoneal_dialysis_patients_a_propensity_score_analysis/27145671）。