2016年CDC阿片指南后加州毒物控制系统的阿片和苯二氮卓暴露趋势

数据集获取（Figshare）

• 源站标题：Trends in concomitant and single opioid and benzodiazepine exposures reported to the California Poison Control System following the Centers for Disease Control and Prevention release of opioid guidelines in 2016
• DOI：10.6084/m9.figshare.22354301.v1
• 发布日期：2023-03-29
• 文件数：2 个
• 文件总体积：39.22 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/Trends_in_concomitant_and_single_opioid_and_benzodiazepine_exposures_reported_to_the_California_Poison_Control_System_following_the_Centers_for_Disease_Control_and_Prevention_release_of_opioid_guidelines_in_2016/22354301

命令行下载

curl -L -o "ictx_a_2158095_sm1071.docx" "https://ndownloader.figshare.com/files/39784490"
curl -L -o "ictx_a_2158095_sm8576.docx" "https://ndownloader.figshare.com/files/39784496"

文件清单

• ictx_a_2158095_sm1071.docx（14.34 KB）
• ictx_a_2158095_sm8576.docx（24.88 KB）

文件总体积 39.22 KB（源站 API 实测）。

数据说明

In March 2016, the Centers for Disease Control and Prevention released the Guideline for Prescribing Opioids for Chronic Pain, intended for primary care clinicians. One recommendation advised against concurrent prescription of opioids and benzodiazepines. Although existing research suggests a reduction in co-prescribing of these drug classes by clinicians after guideline release, there are limited data assessing its possible effect on patient medical outcomes, such as overdoses.
This retrospective observational study analyzed opioid and benzodiazepine exposures, alone or in combination, reported to the California Poison Control System from January 2012 to June 2021. Interrupted time series analyses identified the difference in monthly call volume between pre- and post-guideline release. For exposures resulting in serious medical outcomes, additional analyses assessed trends and identified associated variables.
There was no significant change in concomitant opioid and benzodiazepine exposures reported to California Poison Control System between pre- and post-guideline release. Compared to pre-guideline release, exposures to a single opioid or to a single benzodiazepine significantly decreased by 1.07 (95% CI: −1.62, −0.51) and 1.82 (95% CI: −2.33, −1.31) calls per month, respectively, after the guideline release. For exposure calls associated with serious medical outcomes, there was a significant increase of 0.11 (95% CI: 0.04, 0.18) and 0.2 (95% CI: 0.05, 0.34) calls per month for concomitant opioid and benzodiazepine and single opioid exposures, respectively, following guideline release.
The guideline release appeared to have a variable association with exposures to single opioid, single benzodiazepines, and concomitant opioid and benzodiazepine cases reported to California Poison Control System. Although exposures to opioids or benzodiazepines alone significantly decreased after guideline release, there was no significant change in concomitant exposures. Additionally, for exposures associated with serious medical outcomes, concomitant exposures, and single opioid exposures significantly increased following guideline release.
Our results suggest that the gu

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.22354301.v1（source: https://tandf.figshare.com/articles/dataset/Trends_in_concomitant_and_single_opioid_and_benzodiazepine_exposures_reported_to_the_California_Poison_Control_System_following_the_Centers_for_Disease_Control_and_Prevention_release_of_opioid_guidelines_in_2016/22354301）。