Integrated Analysis of Dysregulated lncRNA Expression in Fetal Cardiac Tissues with Ventricular Septal Defect
This dataset focuses on ventricular septal defect (VSD), the most common form of congenital heart disease, by comparing transcriptome profiles of cardiac tissues from VSD-affected fetuses and normal hearts using a second-generation lncRNA microarray. It covers 29,241 lncRNAs and 30,215 coding transcripts, identifying 880 upregulated and 628 downregulated lncRNAs, with two lncRNAs, ENST00000513542 and RP11-473L15.2, specifically associated with VSD. The data, derived from gene expression analysis of heart tissue samples, aims to elucidate the role of lncRNAs in VSD etiology and provides a reference for studying the interplay between non-coding RNAs and cardiac development.
基本信息
About
This dataset focuses on ventricular septal defect (VSD), the most common form of congenital heart disease, by comparing transcriptome profiles of cardiac tissues from VSD-affected fetuses and normal hearts using a second-generation lncRNA microarray. It covers 29,241 lncRNAs and 30,215 coding transcripts, identifying 880 upregulated and 628 downregulated lncRNAs, with two lncRNAs, ENST00000513542 and RP11-473L15.2, specifically associated with VSD. The data, derived from gene expression analysis of heart tissue samples, aims to elucidate the role of lncRNAs in VSD etiology and provides a reference for studying the interplay between non-coding RNAs and cardiac development.
https://figshare.com/articles/dataset/_Integrated_Analysis_of_Dysregulated_lncRNA_Expression_in_Fetal_Cardiac_Tissues_with_Ventricular_Septal_Defect_/824785
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数据说明
该数据集聚焦于先天性心脏病中最常见的室间隔缺损（VSD），通过第二代lncRNA微阵列技术，比较了VSD患儿与正常胎儿心脏组织的转录组谱。数据集覆盖了29,241个lncRNA和30,215个编码转录本，共识别出880个上调与628个下调的lncRNA，并筛选出ENST00000513542和RP11-473L15.2两个与VSD相关的lncRNA。数据来源于心脏组织样本的基因表达分析，旨在揭示lncRNA在VSD发病机制中的作用，为心脏发育与非编码RNA的相互作用研究提供参考资源。
Accuracy bottleneck? Data gaps?
Current open data not meeting your algorithm needs? We provide high-quality, multimodal real-world clinical data customized for Ventricular septal defect (VSD).
