TGF-β中和增强AngII诱导的胸腹主动脉破裂和动脉瘤

资源简介

TGF-β中和增强AngII诱导的胸腹主动脉破裂和动脉瘤

【数据集背景】

本数据集源站标题为《TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions》。配套论文《TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0153811。源站首次发布：2016-04-22。

【数据内容】

源站原始描述：AngII and TGF-β interact in development of thoracic and abdominal aortic diseases, although there are many facets of this interaction that have not been clearly defined. The aim of the present study was to determine the effects of TGF-β neutralization on AngII induced-aortic pathologies. Male C57BL/6J mice were administered with either a rabbit or mouse TGF-β neutralizing antibody and then infused with AngII. The rabbit TGF-β antibody modestly reduced serum TGF-β concentrations, with no signific…

【数据结构与技术规格】

文件数 17 个，合计 14.66 MB。S1 Fig.PDF：application/pdf，66.75 KB。S16 Fig.PDF：application/pdf，563.07 KB。S15 Fig.PDF：application/pdf，1.53 MB。数据集 DOI：10.1371/journal.pone.0153811。

【主题与分类】

源站学科分类：Medicine、Cell Biology、Molecular Biology、Ecology、Immunology、Developmental Biology。主题标签：suprarenal aortic regions、1 D 11 antibody、suprarenal aortic dilatation、TGF、Abdominal Regions AngII、Male C 57BL mice、28 days。

【适用方向】

源站学科分类标注为 Medicine、Cell Biology、Molecular Biology、Ecology、Immunology、Developmental Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/TGF_Neutralization_Enhances_AngII_Induced_Aortic_Rupture_and_Aneurysm_in_Both_Thoracic_and_Abdominal_Regions/3197593

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Chen, Xiaofeng; L. Rateri, Debra; A. Howatt, Deborah; Balakrishnan, Anju; J. Moorleghen, Jessica; A. Cassis, Lisa; et al. (2016). TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。