DrugTargetWorld
DrugTargetWorld是一个合成生物库框架，包含54,000名参与者的基因型、蛋白质、健康记录和合成心脏MRI，用于心血管疾病靶点发现。
基本信息
资源简介
DrugTargetWorld
【数据集背景】
本数据集源站标题为《arXiv Query: search_query=&id_list=2610.09558v1&start=0&max_results=1》。源站首次发布：2026-10-07。
【数据内容】
源站原始描述：Drug target discovery requires distinguishing molecules that causally drive disease from those that are merely associated with it. Training and evaluating AI agents to perform this workflow end-to-end is difficult because real world biobanks lack known causal ground truth and participant-level data is access controlled. We introduce DrugTargetWorld, a framework that procedurally generates simulated biobanks, or "worlds," with known but concealed causal structure. Each world contains genotypes, p…
【主题与分类】
主题标签：cs.AI。
【适用方向】
多模态数据适合跨模态对齐、融合建模与联合表征学习方向的研究。
【获取与许可】
源站页面：https://arxiv.org/abs/2610.09558v1
下载信息
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使用方式
数据集说明
本数据集 对应论文数据集（arXiv 预印本）。
数据获取指引
- 打开论文页面获取作者与项目信息：https://arxiv.org/abs/2610.09558v1
- 论文 Data Availability / Code Availability 章节标注了数据实际托管位置；
- 获取到实际数据链接后，按对应平台标准方式下载。
论文摘要：Abstract:Drug target discovery requires distinguishing molecules that causally drive disease from those that are merely associated with it. Training and evaluating AI agents to perform this workflow end-to-end is difficult because real world biobanks lack known causal ground truth and participant-level data is access controlled. We introduce DrugTargetWorld, a framework that procedurally generates simulated biobanks, or "worlds," with known but concealed causal structure. Each world contains genotypes, proteins, health records, outcomes, and synthetic magnetic resonance imaging (MRI) for 54,000 participants. Agents must construct a disease phenotype, identify causal driver proteins, infer the beneficial direction of modulation, and optionally conduct virtual 'wet lab' experiments. We evaluated nine agents in 540 episodes across 20 cardiovascular worlds and three experimental budgets. Opus 5 and GPT-5.6 Sol achieved the highest mean composite scores, 39.98 and 35.38 of 100, respectively, and both recovered 64% of causal drivers on average. However, no agent reliably distinguished misleading non-causal proteins, and performance remained limited by the integrative judgments required to connect phenotype construction, causal evidence, and intervention decisions. By making each world's causal structure known to the evaluator but hidden from the agent, DrugTargetWorld turns end-to-end drug target discovery into a scalable training and evaluation problem with verifiable reward.
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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