H19 lncRNA遗传变异与扩张型心肌病关联数据集

资源简介

H19 lncRNA遗传变异与扩张型心肌病关联数据集

【数据集背景】

本数据集源站标题为《A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy》。配套论文《A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy》发表于 RNA Biology（2021），DOI：10.1080/15476286.2021.1952756。项目资助方：This work was supported by the Deutsche Forschungsgemeinschaft [281125614/GRK 2220]; Else Kröner-Fresenius-Stiftung [No.: 2018_EKES.38]; Innovative Medical Research of the University of Münster Medical School [RÜ121510].。源站首次发布：2021-07-27。

【数据内容】

源站原始描述：lncRNAs are at the core of many regulatory processes and have also been recognized to be involved in various complex diseases. They affect gene regulation through direct interactions with RNA, DNA or proteins. Accordingly, lncRNA structure is likely to be essential for their regulatory function. Point mutations, which manifest as SNPs (single nucleotide polymorphisms) in genome screens, can substantially alter their function and, subsequently, the expression of their downstream regulated genes.…

文件 figureS1.ps 为文本内容，开头为：%!PS-Adobe-3.0 %%Creator: cairo 1.14.6 (http://cairographics.org) %%CreationDate: Thu Aug 6 17:18:37 2020 %%Pages: 1 %%DocumentData: Clean7Bit %%LanguageLevel…

【数据结构与技术规格】

文件数 3 个，合计 5.82 MB。Supplement Table_rev2.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，313.22 KB。downloadFromZipFile.pdf：application/pdf，733.50 KB。figureS1.ps：application/postscript，4.78 MB。数据集 DOI：10.6084/m9.figshare.15060842.v1。

【主题与分类】

源站学科分类：Biophysics、Medicine、Genetics、Chemical Sciences not elsewhere classified、Biological Sciences not elsewhere classified、Cancer。主题标签：RNA structure、lncRNA、cardiovascular disease、RiboSNitch、Boltzmann ensemble、minimum free energy、SHAPE-Seq、H19、rs217727、SNP。

【适用方向】

源站学科分类标注为 Biophysics、Medicine、Genetics、Chemical Sciences not elsewhere classified、Biological Sciences not elsewhere classified、Cancer。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/A_genetic_variant_alters_the_secondary_structure_of_the_lncRNA_H19_and_is_associated_with_dilated_cardiomyopathy/15060842

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. Taylor & Francis. Martens, Leonie; Rühle, Frank; Witten, Anika; Meder, Benjamin; Katus, Hugo A.; Arbustini, Eloisa; et al

【使用注意】

· 源站最后修改于 2024-03-21，引用时请注意版本时效。