冠状动脉钙化检测用于冠心病和心血管疾病风险预测以指导他汀分配的成本效果：多民族动脉粥样硬化研究（MESA）

数据集获取（Figshare）

• 源站标题：Cost-Effectiveness of Coronary Artery Calcium Testing for Coronary Heart and Cardiovascular Disease Risk Prediction to Guide Statin Allocation: The Multi-Ethnic Study of Atherosclerosis (MESA)
• DOI：10.1371/journal.pone.0116377
• 发布日期：2015-03-18
• 文件数：4 个
• 文件总体积：75.64 KB
• 源站页面：https://plos.figshare.com/articles/dataset/_Cost_Effectiveness_of_Coronary_Artery_Calcium_Testing_for_Coronary_Heart_and_Cardiovascular_Disease_Risk_Prediction_to_Guide_Statin_Allocation_The_Multi_Ethnic_Study_of_Atherosclerosis_MESA_/1340729

命令行下载

curl -L -o "S1_Methods.docx" "https://ndownloader.figshare.com/files/1957387"
curl -L -o "S1_Table.docx" "https://ndownloader.figshare.com/files/1957388"
curl -L -o "S2_Table.docx" "https://ndownloader.figshare.com/files/1957389"
curl -L -o "S3_Table.docx" "https://ndownloader.figshare.com/files/1957390"

文件清单

• S1_Methods.docx（16.21 KB）
• S1_Table.docx（17.40 KB）
• S2_Table.docx（22.58 KB）
• S3_Table.docx（19.46 KB）

文件总体积 75.64 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
The Multi-Ethnic Study of Atherosclerosis (MESA) showed that the addition of coronary artery calcium (CAC) to traditional risk factors improves risk classification, particularly in intermediate risk asymptomatic patients with LDL cholesterol levels Objective
To model the cost-effectiveness of CAC for cardiovascular risk stratification in asymptomatic, intermediate risk patients not taking a statin. Treatment based on CAC was compared to (1) treatment of all intermediate-risk patients, and (2) treatment on the basis of United States guidelines.
Methods
We developed a Markov model of first coronary heart disease (CHD) and cardiovascular disease (CVD) events. We modeled statin treatment in intermediate risk patients with CAC≥1 and CAC≥100, with different intensities of statins based on the CAC score. We compared these CAC-based treatment strategies to a “treat all” strategy and to treatment according to the Adult Treatment Panel III (ATP III) guidelines. Clinical and economic outcomes were modeled over both five- and ten-year time horizons. Outcomes consisted of CHD and CVD events and Quality-Adjusted Life Years (QALYs). Sensitivity analyses considered the effect of higher event rates, different CAC and statin costs, indirect costs, and re-scanning patients with incidentalomas.
Results
We project that it is both cost-saving and more effective to scan intermediate-risk patients for CAC and to treat those with CAC≥1, compared to treatment based on established risk-assessment guidelines. Treating patients with CAC≥100 is also preferred to existing guidelines when we account for statin side effects and the disutility of statin use.
Conclusion
Compared to the alternatives we assessed, CAC testing is both effective and cost saving as a risk-stratification tool, particularly if there are adverse effects of long-term statin use. CAC may enable providers to better tailor preventive therapy to patients’’ risks of CVD.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0116377（source: https://plos.figshare.com/articles/dataset/_Cost_Effectiveness_of_Coronary_Artery_Calcium_Testing_for_Coronary_Heart_and_Cardiovascular_Disease_Risk_Prediction_to_Guide_Statin_Allocation_The_Multi_Ethnic_Study_of_Atherosclerosis_MESA_/1340729）。