非肺静脉介导的心房颤动：一种新的亚表型

数据集获取（Figshare）

• 源站标题：Non-pulmonary vein mediated atrial fibrillation: A novel sub-phenotype
• DOI：10.1371/journal.pone.0184354
• 发布日期：2017-09-07
• 文件数：3 个
• 文件总体积：635.31 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Non-pulmonary_vein_mediated_atrial_fibrillation_A_novel_sub-phenotype/5385910

命令行下载

curl -L -o "S1 Table.tif" "https://ndownloader.figshare.com/files/9275539"
curl -L -o "S2 Table.tif" "https://ndownloader.figshare.com/files/9275560"
curl -L -o "S3 Table.tif" "https://ndownloader.figshare.com/files/9275563"

文件清单

• S1 Table.tif（284.41 KB）
• S2 Table.tif（285.46 KB）
• S3 Table.tif（65.44 KB）

文件总体积 635.31 KB（源站 API 实测）。

数据说明

Background
Atrial fibrillation (AF) is a mechanistically heterogeneous disorder, and the ability to identify sub-phenotypes (“endophenotypes”) of AF would assist in the delivery of personalized medicine. We used the clinical response to pulmonary vein isolation (PVI) to identify a sub-group of patients with non-PV mediated AF and sought to define the clinical associations.
Methods
Subjects enrolled in the Vanderbilt AF Ablation Registry who underwent a repeat AF ablation due to arrhythmia recurrence were analyzed on the basis of PV reconnection. Subjects who had no PV reconnection were defined as “non-PV mediated AF”. A comparison group of subjects were identified who had AF that was treated with PVI-only and experienced no arrhythmia recurrence >12 months. They were considered a group enriched for “PV-mediated AF”. Univariate and multivariable binary logistic regression analysis was performed to investigate clinical associations between the PV and non-PV mediated AF groups.
Results
Two hundred and twenty nine subjects underwent repeat AF ablation and thirty three (14%) had no PV reconnection. They were compared with 91 subjects identified as having PV-mediated AF. Subjects with non-PV mediated AF were older (64 years [IQR 60,71] vs. 60 [52,67], P = 0.01), more likely to have non-paroxysmal AF (82% [N = 27] vs. 35% [N = 32], PConclusions
Non-paroxysmal AF was the only clinical variable found to be independently associated with non-PV mediated AF. We demonstrated that analysis of AF ablation outcomes data can serve as a tool to successfully identify a sub-phenotype of subjects who have non-PV mediated AF.
Clinical trial registration
ClinicalTrials.gov ID # NCT02404415.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0184354（source: https://plos.figshare.com/articles/dataset/Non-pulmonary_vein_mediated_atrial_fibrillation_A_novel_sub-phenotype/5385910）。