药师主导协作干预改善他汀处方与胆固醇目标达成的集群随机对照试验数据集

数据集获取（Figshare）

• 源站标题：A Cluster Randomised Controlled Trial of a Pharmacist-Led Collaborative Intervention to Improve Statin Prescribing and Attainment of Cholesterol Targets in Primary Care
• DOI：10.1371/journal.pone.0113370
• 发布日期：2014-11-18
• 文件数：3 个
• 文件总体积：2.91 MB
• 源站页面：https://plos.figshare.com/articles/dataset/_A_Cluster_Randomised_Controlled_Trial_of_a_Pharmacist_Led_Collaborative_Intervention_to_Improve_Statin_Prescribing_and_Attainment_of_Cholesterol_Targets_in_Primary_Care_/1245677

命令行下载

curl -L -o "File_S1.docx" "https://ndownloader.figshare.com/files/1799205"
curl -L -o "Checklist_S1.docx" "https://ndownloader.figshare.com/files/1799206"
curl -L -o "Protocol_S1.doc" "https://ndownloader.figshare.com/files/1799207"

文件清单

• File_S1.docx（2.09 MB）
• Checklist_S1.docx（27.30 KB）
• Protocol_S1.doc（794.11 KB）

文件总体积 2.91 MB（源站 API 实测）。

数据说明

Background
Small trials with short term follow up suggest pharmacists’ interventions targeted at healthcare professionals can improve prescribing. In comparison with clinical guidance, contemporary statin prescribing is sub-optimal and achievement of cholesterol targets falls short of accepted standards, for patients with atherosclerotic vascular disease who are at highest absolute risk and who stand to obtain greatest benefit. We hypothesised that a pharmacist-led complex intervention delivered to doctors and nurses in primary care, would improve statin prescribing and achievement of cholesterol targets for incident and prevalent patients with vascular disease, beyond one year.
Methods
We allocated general practices to a 12-month Statin Outreach Support (SOS) intervention or usual care. SOS was delivered by one of 11 pharmacists who had received additional training. SOS comprised academic detailing and practical support to identify patients with vascular disease who were not prescribed a statin at optimal dose or did not have cholesterol at target, followed by individualised recommendations for changes to management. The primary outcome was the proportion of patients achieving cholesterol targets. Secondary outcomes were: the proportion of patients prescribed simvastatin 40 mg with target cholesterol achieved; cholesterol levels; prescribing of simvastatin 40 mg; prescribing of any statin and the proportion of patients with cholesterol tested. Outcomes were assessed after an average of 1.7 years (range 1.4–2.2 years), and practice level simvastatin 40 mg prescribing was assessed after 10 years.
Findings
We randomised 31 practices (72 General Practitioners (GPs), 40 nurses). Prior to randomisation a subset of eligible patients were identified to characterise practices; 40% had cholesterol levels below the target threshold. Improvements in data collection procedures allowed identification of all eligible patients (n = 7586) at follow up. Patients in practices allocated to SOS were significantly more likely to have cholesterol at target (69.5% vs 63.5%; OR 1.11, CI 1.00–1.23; p = 0.043) as a result of improved simvastatin prescribing. Subgroup analysis showed the

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0113370（source: https://plos.figshare.com/articles/dataset/_A_Cluster_Randomised_Controlled_Trial_of_a_Pharmacist_Led_Collaborative_Intervention_to_Improve_Statin_Prescribing_and_Attainment_of_Cholesterol_Targets_in_Primary_Care_/1245677）。