Hedgehog通路拮抗剂诱导前脑无裂畸形、唇裂和腭裂关键期定义数据集

资源简介

Hedgehog通路拮抗剂诱导前脑无裂畸形、唇裂和腭裂关键期定义数据集

【数据集背景】

本数据集源站标题为《Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate》。配套论文《Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0120517。源站首次发布：2015-03-20。

【数据内容】

源站原始描述：The Hedgehog (Hh) signaling pathway mediates multiple spatiotemporally-specific aspects of brain and face development. Genetic and chemical disruptions of the pathway are known to result in an array of structural malformations, including holoprosencephaly (HPE), clefts of the lip with or without cleft palate (CL/P), and clefts of the secondary palate only (CPO). Here, we examined patterns of dysmorphology caused by acute, stage-specific Hh signaling inhibition. Timed-pregnant wildtype C57BL/6J m…

【数据结构与技术规格】

文件数 8 个，合计 27.59 MB。S2_Fig.tif：image/tiff，142.99 KB。数据集 DOI：10.1371/journal.pone.0120517。

【主题与分类】

源站学科分类：Biological Sciences。主题标签：cpo、GD 8.875. Insult、57BL、GD 7.5. Unilateral clefts、Hh pathway disruption、cl、palate、tractable mouse model、pathway antagonist vismodegib、hpe。

【适用方向】

源站学科分类标注为 Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Definition_of_Critical_Periods_for_Hedgehog_Pathway_Antagonist_Induced_Holoprosencephaly_Cleft_Lip_and_Cleft_Palate_/1345561

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：W. Heyne, Galen; G. Melberg, Cal; Doroodchi, Padydeh; F. Parins, Kia; W. Kietzman, Henry; L. Everson, Joshua; et al. (2016). Definition of Critical Periods for Hedgehog Pathway Antagonist-Induced Holoprosencephaly, Cleft Lip, and Cleft Palate. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。