严重肥胖及医疗减重对估算肾小球滤过率的影响

数据集获取（Figshare）

• 源站标题：Severe obesity and the impact of medical weight loss on estimated glomerular filtration rate
• DOI：10.6084/m9.figshare.11774520.v1
• 发布日期：2020-01-31
• 文件数：1 个
• 文件总体积：30.01 KB
• 源站页面：https://figshare.com/articles/dataset/Severe_obesity_and_the_impact_of_medical_weight_loss_on_estimated_glomerular_filtration_rate/11774520

命令行下载

curl -L -o "dataset for PLOSone 110819.csv" "https://ndownloader.figshare.com/files/21488439"

文件清单

• dataset for PLOSone 110819.csv（30.01 KB）

文件总体积 30.01 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Objective:
To assess the impact of obesity, glucose tolerance, and weight loss on renal
function, we measured serum creatinine and cystatin C and estimated glomerular
filtration rate (GFR) indexed to 1.73m2 body surface area (BSA) and
GFR indexed to actual BSA in subjects with normal and abnormal glucose
tolerance before and up to 2 years after medical weight loss.

Methods: We
studied 146 subjects at baseline and 3-to-6 months after 18% reduction in
weight; 43 were also studied at 2-years.
GFR was estimated using the MDRD, CKD-EPICr, CKD-EPICysCr,
and the CKD-EPICys equations.

Results:
eGFR was consistently lower when creatinine-based rather than cystatin C-based
estimating equations were used. eGFR was lower when creatinine-based or
cystatin C-based equations were indexed to 1.73m2 BSA than when they
were indexed to actual BSA. eGFR indexed to actual BSA was more likely to
demonstrate hyperfiltration (eGFR ≥135 ml/min) than eGFR indexed to 1.73m2
BSA and decreased into the normal range with weight loss. eGFR was highest in
subjects with impaired fasting glucose but there was little difference in the
patterns of change in eGFR across groups by glucose tolerance status.

Conclusions:
With severe obesity, high fat-free mass and BSA result in low estimates of eGFR
indexed to 1.73m2 BSA, especially when creatinine-based estimating
equations are used. GFR indexed to actual BSA is approximately 50% higher. When
eGFR is indexed to actual BSA, many subjects display evidence of renal
hyperfiltration which improves with weight loss. In subjects with severe
obesity undergoing medical weight loss, estimating equations that use cystatin
C and are indexed to actual BSA may provide a more accurate assessment of renal
function.

许可

CC0

引用

学术使用请引用 DOI 10.6084/m9.figshare.11774520.v1（source: https://figshare.com/articles/dataset/Severe_obesity_and_the_impact_of_medical_weight_loss_on_estimated_glomerular_filtration_rate/11774520）。