持续肾脏替代治疗危重儿童药物剂量优化：从基本概念到床边模型指导的精准给药
危重儿童CRRT下药物剂量优化的文献数据集，涵盖药代动力学与模型指导给药。
基本信息
资源简介
持续肾脏替代治疗危重儿童药物剂量优化：从基本概念到床边模型指导的精准给药
【一句话概览】
本数据集是 figshare 公开的文本数据集，收录 2 个文件、合计 1.64 MB，主题涵盖 Children、pharmacokinetics、precision dosing、renal replacement therapy、modelling，可用于医学自然语言处理（实体识别、信息抽取等），CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing》。配套论文《Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing》发表于 Expert Opinion on Drug Metabolism & Toxicology（2024），DOI：10.1080/17425255.2024.2422875。项目资助方：This paper was not funded.。源站首次发布：2024-10-29。
【数据内容】
源站原始描述：Optimizing drug dosage in critically ill children undergoing Continuous Renal Replacement Therapy (CRRT) is mandatory and challenging, given the many factors impacting pharmacokinetics and pharmacodynamics coupled with the vulnerability of this population. A good understanding of the mechanisms that determine drug elimination via the CRRT technique is useful to avoid prescription pitfalls, however limited by the high between and within subject variability. The developments of population pharmaco…
【数据结构与技术规格】
文件数 2 个，合计 1.64 MB。iemt_a_2422875_sm7144.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，1.13 MB。iemt_a_2422875_sm7143.tiff：image/tiff，507.92 KB。数据集 DOI：10.6084/m9.figshare.27324884.v1。
【主题与分类】
源站学科分类：Medicine、Genetics、Pharmacology、Biotechnology、Biological Sciences not elsewhere classified、Information Systems not elsewhere classified。主题标签：Children、pharmacokinetics、precision dosing、renal replacement therapy、modelling。
【适用方向】
文本类数据可用于医学自然语言处理，如命名实体识别、信息抽取与文本分类。
【获取与许可】
源站页面：https://tandf.figshare.com/articles/dataset/Drug_dosing_optimization_in_critically_ill_children_under_continuous_renal_replacement_therapy_from_basic_concepts_to_the_bedside_model_informed_precision_dosing/27324884
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing. Taylor & Francis. Oualha, Mehdi; Thy, Michael; Bouazza, Naïm; Benaboud, Sihem; Béranger, Agathe
【使用注意】
· 源站最后修改于 2025-02-01，引用时请注意版本时效。
下载信息
注册下载
需要注册 Kaggle 账号并登录后下载，适合需要跟踪下载记录和使用 API 的用户。
暂未开放公开下载
无需注册即可直接获取公开样本或文档，适合快速预览和评估数据集质量。
免登录有偿下载
公开数据集受托下载与技术交付服务。
提供高速下载与技术交付服务（收技术服务费，非数据销售）
暂未开放当前数据集主要来源为 Kaggle 公开托管，完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取（Figshare）
- 源站标题：Drug dosing optimization in critically ill children under continuous renal replacement therapy: from basic concepts to the bedside model informed precision dosing
- DOI：10.6084/m9.figshare.27324884.v1
- 发布日期：2024-10-29
- 文件数：2 个
- 文件总体积：1.64 MB
- 源站页面：https://tandf.figshare.com/articles/dataset/Drug_dosing_optimization_in_critically_ill_children_under_continuous_renal_replacement_therapy_from_basic_concepts_to_the_bedside_model_informed_precision_dosing/27324884
命令行下载
curl -L -o "iemt_a_2422875_sm7144.docx" "https://ndownloader.figshare.com/files/50059913"
curl -L -o "iemt_a_2422875_sm7143.tiff" "https://ndownloader.figshare.com/files/50059916"
文件清单
iemt_a_2422875_sm7144.docx（1.13 MB）iemt_a_2422875_sm7143.tiff（507.92 KB）
文件总体积 1.64 MB（源站 API 实测）。
数据说明
Optimizing drug dosage in critically ill children undergoing Continuous Renal Replacement Therapy (CRRT) is mandatory and challenging, given the many factors impacting pharmacokinetics and pharmacodynamics coupled with the vulnerability of this population.
A good understanding of the mechanisms that determine drug elimination via the CRRT technique is useful to avoid prescription pitfalls, however limited by the high between and within subject variability. The developments of population pharmacokinetic and physiologically based pharmacokinetic models derived from in-vivo and in-vitro studies, are challenging, but remain the most appropriate tool to suggest adjusted dosage regimens for every patient, throughout treatment. We searched PubMed using the search string: ‘pediatrics OR children’ AN ‘continuous renal replacement therapy’ AND ‘pharmacokinetics’ AND ‘model informed precision dosing’ AND, ‘physiologically based pharmacokinetics,’ AND ‘therapeutic drug monitoring’ until January 2024, regardless of language or publication status.
Familiarizing the pediatric intensivists with the therapeutic drug monitoring and providing clinicians the individualized prescribing software such as Model Informed Precision Dosing would be a significant step forward. The clinical benefit for patients remains to be demonstrated.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.6084/m9.figshare.27324884.v1（source: https://tandf.figshare.com/articles/dataset/Drug_dosing_optimization_in_critically_ill_children_under_continuous_renal_replacement_therapy_from_basic_concepts_to_the_bedside_model_informed_precision_dosing/27324884）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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