肿瘤来源的Suppressor of Fused突变揭示Hedgehog通路相互作用数据集

资源简介

肿瘤来源的Suppressor of Fused突变揭示Hedgehog通路相互作用数据集

【数据集背景】

本数据集源站标题为《Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions》。配套论文《Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions》发表于 PLOS ONE（2016），DOI：10.1371/journal.pone.0168031。源站首次发布：2016-12-28。

【数据内容】

源站原始描述：The Hedgehog pathway is a potent regulator of cellular growth and plays a central role in the development of many cancers including basal cell carcinoma (BCC). The majority of BCCs arise from mutations in the Patched receptor resulting in constitutive activation of the Hedgehog pathway. Secondary driver mutations promote BCC oncogenesis and occur frequently due to the high mutational burden resulting from sun exposure of the skin. Here, we uncover novel secondary mutations in Suppressor of Fused…

【数据结构与技术规格】

文件数 2 个，合计 2.15 MB。S1 Fig.eps：application/postscript，992.09 KB。S2 Fig.eps：application/postscript，1.16 MB。数据集 DOI：10.1371/journal.pone.0168031。

【主题与分类】

源站学科分类：Biophysics、Microbiology、Cell Biology、Genetics、Molecular Biology、Environmental Sciences not elsewhere classified。主题标签：GLI、Hedgehog pathway、function SUFU variants、constitutive pathway activation、Fused Mutations Reveal Hedgehog Pathway Interactions、basal cell carcinoma、Hedgehog transcriptional activator、Hedgehog target genes、Secondary driver mutations、drive BCC formation。

【适用方向】

源站学科分类标注为 Biophysics、Microbiology、Cell Biology、Genetics、Molecular Biology、Environmental Sciences not elsewhere classified。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Tumor-Derived_Suppressor_of_Fused_Mutations_Reveal_Hedgehog_Pathway_Interactions/4500185

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Urman, Nicole M.; Mirza, Amar; Atwood, Scott X.; Whitson, Ramon J.; Sarin, Kavita Y.; Tang, Jean Y.; et al. (2016). Tumor-Derived Suppressor of Fused Mutations Reveal Hedgehog Pathway Interactions. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-03，引用时请注意版本时效。