丝质服装联合标准护理与单独标准护理治疗儿童湿疹的比较（CLOTHES试验）

数据集获取（Figshare）

• 源站标题：Silk garments plus standard care compared with standard care for treating eczema in children: A randomised, controlled, observer-blind, pragmatic trial (CLOTHES Trial)
• DOI：10.1371/journal.pmed.1002280
• 发布日期：2017-04-11
• 文件数：15 个
• 文件总体积：902.64 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Silk_garments_plus_standard_care_compared_with_standard_care_for_treating_eczema_in_children_A_randomised_controlled_observer-blind_pragmatic_trial_CLOTHES_Trial_/4865519

命令行下载

curl -L -o "S1 Alternative Language Abstract.docx" "https://ndownloader.figshare.com/files/8101697"
curl -L -o "S2 Alternative Language Abstract.doc" "https://ndownloader.figshare.com/files/8101715"
curl -L -o "S3 Alternative Language Abstract.docx" "https://ndownloader.figshare.com/files/8101727"
curl -L -o "S4 Alternative Language Abstract.docx" "https://ndownloader.figshare.com/files/8101733"
curl -L -o "S5 Alternative Language Abstract.docx" "https://ndownloader.figshare.com/files/8101736"
curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/8101757"
curl -L -o "S2 Table.docx" "https://ndownloader.figshare.com/files/8101769"
curl -L -o "S3 Table.docx" "https://ndownloader.figshare.com/files/8101787"

文件清单

• S1 Alternative Language Abstract.docx（16.13 KB）
• S2 Alternative Language Abstract.doc（28.16 KB）
• S3 Alternative Language Abstract.docx（14.71 KB）
• S4 Alternative Language Abstract.docx（17.04 KB）
• S5 Alternative Language Abstract.docx（15.30 KB）
• S1 Table.docx（22.98 KB）
• S2 Table.docx（14.44 KB）
• S3 Table.docx（17.56 KB）
• S4 Table.docx（15.78 KB）
• S5 Table.docx（13.96 KB）
• S6 Table.docx（17.31 KB）
• S7 Table.docx（16.73 KB）
• S8 Table.docx（13.11 KB）
• S1 Protocol.pdf（455.66 KB）
• S1 Checklist.doc（223.74 KB）

文件总体积 902.64 KB（源站 API 实测）。

数据说明

Background
The role of clothing in the management of eczema (also called atopic dermatitis or atopic eczema) is poorly understood. This trial evaluated the effectiveness and cost-effectiveness of silk garments (in addition to standard care) for the management of eczema in children with moderate to severe disease.
Methods and findings
This was a parallel-group, randomised, controlled, observer-blind trial. Children aged 1 to 15 y with moderate to severe eczema were recruited from secondary care and the community at five UK medical centres. Participants were allocated using online randomisation (1:1) to standard care or to standard care plus silk garments, stratified by age and recruiting centre. Silk garments were worn for 6 mo. Primary outcome (eczema severity) was assessed at baseline, 2, 4, and 6 mo, by nurses blinded to treatment allocation, using the Eczema Area and Severity Index (EASI), which was log-transformed for analysis (intention-to-treat analysis). A safety outcome was number of skin infections.
Three hundred children were randomised (26 November 2013 to 5 May 2015): 42% girls, 79% white, mean age 5 y. Primary analysis included 282/300 (94%) children (n = 141 in each group). The garments were worn more often at night than in the day (median of 81% of nights [25th to 75th centile 57% to 96%] and 34% of days [25th to 75th centile 10% to 76%]). Geometric mean EASI scores at baseline, 2, 4, and 6 mo were, respectively, 9.2, 6.4, 5.8, and 5.4 for silk clothing and 8.4, 6.6, 6.0, and 5.4 for standard care. There was no evidence of any difference between the groups in EASI score averaged over all follow-up visits adjusted for baseline EASI score, age, and centre: adjusted ratio of geometric means 0.95, 95% CI 0.85 to 1.07, (p = 0.43). This confidence interval is equivalent to a difference of −1.5 to 0.5 in the original EASI units, which is not clinically important. Skin infections occurred in 36/142 (25%) and 39/141 (28%) of children in the silk clothing and standard care groups, respectively. Even if the small observed treatment effect was genuine, the incremental cost per quality-adjusted life year was £56,811 in the base case analysis from a National He

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002280（source: https://plos.figshare.com/articles/dataset/Silk_garments_plus_standard_care_compared_with_standard_care_for_treating_eczema_in_children_A_randomised_controlled_observer-blind_pragmatic_trial_CLOTHES_Trial_/4865519）。