改善尼日利亚儿童和新生儿临床护理与结局的氧气系统：阶梯楔形整群随机试验

数据集获取（Figshare）

• 源站标题：Oxygen systems to improve clinical care and outcomes for children and neonates: A stepped-wedge cluster-randomised trial in Nigeria
• DOI：10.1371/journal.pmed.1002951
• 发布日期：2019-11-11
• 文件数：8 个
• 文件总体积：1.68 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Oxygen_systems_to_improve_clinical_care_and_outcomes_for_children_and_neonates_A_stepped-wedge_cluster-randomised_trial_in_Nigeria/10284398

命令行下载

curl -L -o "pmed.1002951.s001.docx" "https://ndownloader.figshare.com/files/18658121"
curl -L -o "pmed.1002951.s002.tif" "https://ndownloader.figshare.com/files/18658124"
curl -L -o "pmed.1002951.s003.docx" "https://ndownloader.figshare.com/files/18658127"
curl -L -o "pmed.1002951.s004.docx" "https://ndownloader.figshare.com/files/18658130"
curl -L -o "pmed.1002951.s005.docx" "https://ndownloader.figshare.com/files/18658133"
curl -L -o "pmed.1002951.s006.docx" "https://ndownloader.figshare.com/files/18658136"
curl -L -o "pmed.1002951.s007.docx" "https://ndownloader.figshare.com/files/18658139"
curl -L -o "pmed.1002951.s008.docx" "https://ndownloader.figshare.com/files/18658142"

文件清单

• pmed.1002951.s001.docx（28.54 KB）
• pmed.1002951.s002.tif（1.49 MB）
• pmed.1002951.s003.docx（45.41 KB）
• pmed.1002951.s004.docx（20.58 KB）
• pmed.1002951.s005.docx（27.97 KB）
• pmed.1002951.s006.docx（14.76 KB）
• pmed.1002951.s007.docx（23.28 KB）
• pmed.1002951.s008.docx（37.58 KB）

文件总体积 1.68 MB（源站 API 实测）。

数据说明

Background
Improving oxygen systems may improve clinical outcomes for hospitalised children with acute lower respiratory infection (ALRI). This paper reports the effects of an improved oxygen system on mortality and clinical practices in 12 general, paediatric, and maternity hospitals in southwest Nigeria.
Methods and findings
We conducted an unblinded stepped-wedge cluster-randomised trial comparing three study periods: baseline (usual care), pulse oximetry introduction, and stepped introduction of a multifaceted oxygen system. We collected data from clinical records of all admitted neonates (p = 0.721) or children with ALRI (aOR 1.09; 95% CI 0.50–2.41; p = 0.824) and was associated with an increased risk of death for neonates overall (aOR 1.45; 95% CI 1.04–2.00; p = 0.026) but not preterm/low-birth-weight neonates (aOR 1.30; 95% CI 0.76–2.23; p = 0.366). Secondary analyses suggested that the introduction of pulse oximetry improved oxygen practices prior to implementation of the full oxygen system and was associated with lower odds of death for children with ALRI (aOR 0.33; 95% CI 0.12–0.92; p = 0.035) but not for children, preterm neonates, or neonates overall (aOR 0.97, 95% CI 0.60–1.58, p = 0.913; aOR 1.12, 95% CI 0.56–2.26, p = 0.762; aOR 0.90, 95% CI 0.57–1.43, p = 0.651). Limitations of our study are a lower-than-anticipated power to detect change in mortality outcomes (low event rates, low participant numbers, high intracluster correlation) and major contextual changes related to the 2016–2017 Nigerian economic recession that influenced care-seeking and hospital function during the study period, potentially confounding mortality outcomes.
Conclusions
We observed no mortality benefit for children and a possible higher risk of neonatal death following the introduction of a multifaceted oxygen system compared to introducing pulse oximetry alone. Where some oxygen is available, pulse oximetry may improve oxygen usage and clinical outcomes for children with ALRI.
Trial registration
Australian New Zealand Clinical Trials Registry: ACTRN12617000341325.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1002951（source: https://plos.figshare.com/articles/dataset/Oxygen_systems_to_improve_clinical_care_and_outcomes_for_children_and_neonates_A_stepped-wedge_cluster-randomised_trial_in_Nigeria/10284398）。