雌激素激活丙酮酸激酶M2并促进TSC2缺陷细胞生长的数据集

资源简介

雌激素激活丙酮酸激酶M2并促进TSC2缺陷细胞生长的数据集

【数据集背景】

本数据集源站标题为《Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells》。配套论文《Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells》发表于 PLOS ONE（2020），DOI：10.1371/journal.pone.0228894。源站首次发布：2020-02-20。

【数据内容】

源站原始描述：Lymphangioleiomyomatosis (LAM) is a devastating lung disease caused by inactivating gene mutations in either TSC1 or TSC2 that result in hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1). As LAM occurs predominantly in women during their reproductive age and is exacerbated by pregnancy, the female hormonal environment, and in particular estrogen, is implicated in LAM pathogenesis and progression. However, detailed underlying molecular mechanisms are not well understood. I…

【数据结构与技术规格】

文件数 5 个，合计 1.20 MB。pone.0228894.s001.tif：image/tiff，246.19 KB。pone.0228894.s002.tif：image/tiff，201.87 KB。pone.0228894.s003.tif：image/tiff，239.69 KB。数据集 DOI：10.1371/journal.pone.0228894。

【主题与分类】

源站学科分类：Biochemistry、Medicine、Microbiology、Cell Biology、Genetics、Molecular Biology。主题标签：PKM 2、estrogen receptor antagonist Faslodex、TSC 2-deficient LAM patient-derived、Estrogen activates pyruvate kinase M 2、inactivating gene mutations、cell culture models、mTORC 1 inhibitor-insensitive manner、phosphorylated PKM 2、pyruvate kinase M 2、mTORC 1-hyperactive cells。

【适用方向】

源站学科分类标注为 Biochemistry、Medicine、Microbiology、Cell Biology、Genetics、Molecular Biology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Estrogen_activates_pyruvate_kinase_M2_and_increases_the_growth_of_TSC2-deficient_cells/11878407

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Lu, Yiyang; Liu, Xiaolei; Zhang, Erik; Kopras, Elizabeth J.; Smith, Eric P.; Astreinidis, Aristotelis; et al. (2020). Estrogen activates pyruvate kinase M2 and increases the growth of TSC2-deficient cells. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-02，引用时请注意版本时效。