灼口综合征钠通道基因表达数据

数据集获取（Figshare）

• 源站标题：Voltage-gated sodium channels gene expression in Burning Mouth Syndrome: a case-control study
• DOI：10.6084/m9.figshare.21936687.v1
• 发布日期：2023-01-21
• 文件数：5 个
• 文件总体积：4.64 MB
• 源站页面：https://scielo.figshare.com/articles/dataset/Voltage-gated_sodium_channels_gene_expression_in_Burning_Mouth_Syndrome_a_case-control_study/21936687

命令行下载

curl -L -o "80a3326e20ffea930d086148a02552396ce7ebbe.tif" "https://ndownloader.figshare.com/files/38914080"
curl -L -o "b0996f976465ba5466f674bb5727b755fdc2b70d.png" "https://ndownloader.figshare.com/files/38914083"
curl -L -o "127858002dc73478d0f2610043443da1f9f79474.jpg" "https://ndownloader.figshare.com/files/38914086"
curl -L -o "Table_1.xls" "https://ndownloader.figshare.com/files/38914089"
curl -L -o "Table_2.xls" "https://ndownloader.figshare.com/files/38914092"

文件清单

• 80a3326e20ffea930d086148a02552396ce7ebbe.tif（4.56 MB）
• b0996f976465ba5466f674bb5727b755fdc2b70d.png（71.44 KB）
• 127858002dc73478d0f2610043443da1f9f79474.jpg（3.63 KB）
• Table_1.xls（5.63 KB）
• Table_2.xls（5.63 KB）

文件总体积 4.64 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Abstract Burning mouth syndrome (BMS) is a condition characterized by painful symptoms of the oral mucosa, despite the absence of any clinical signs. Its etiology is unknown, and there is still no effective treatment to date. Current evidence has shown neuropathic impairment in BMS patients. Neuropathic pain can be related to the dysfunction of voltage-gated sodium channels, considering that these receptors regulate the induction of action potentials in nociceptive neurons. This study evaluated the gene expression of voltage-gated sodium channels Na v 1.7, Na v 1.8 and Na v 1.9 in these patients. The gene expressions of these channels were assessed by real time RT-PCR analysis of fresh-frozen tongue biopsies in a case-control study composed of 12 patients with BMS, and 5 healthy control patients, proportionally matched by sex and age, and analyzed using the 2^(-Delta Delta CT) method. There was no statistically significant difference between the analyzed groups, despite the increase in Na v 1.7 (fold-change = 3.13, p = 0.52) and decrease in Na v 1.9 (fold-change = 0.45, p = 0.36) gene expression in the BMS group. The Na v 1.8 gene was not expressed in any of the samples analyzed. Although the gene expression in the voltage-gated sodium channels in BMS under study seems to be comparable with that of the normal oral mucosa, the functionality of these channels in BMS has not yet been identified, thus suggesting that further research is needed to better understand these voltage-gated sodium channels.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.21936687.v1（source: https://scielo.figshare.com/articles/dataset/Voltage-gated_sodium_channels_gene_expression_in_Burning_Mouth_Syndrome_a_case-control_study/21936687）。