IFNγ抑制G-CSF诱导的中性粒细胞扩增与中枢神经系统侵袭以预防病毒性脑炎

资源简介

IFNγ抑制G-CSF诱导的中性粒细胞扩增与中枢神经系统侵袭以预防病毒性脑炎

【数据集背景】

本数据集源站标题为《IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis》。配套论文《IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis》发表于 PLOS Pathogens（2018），DOI：10.1371/journal.ppat.1006822。源站首次发布：2018-01-19。

【数据内容】

源站原始描述：Emergency hematopoiesis facilitates the rapid expansion of inflammatory immune cells in response to infections by pathogens, a process that must be carefully regulated to prevent potentially life threatening inflammatory responses. Here, we describe a novel regulatory role for the cytokine IFNγ that is critical for preventing fatal encephalitis after viral infection. HSV1 encephalitis (HSE) is triggered by the invasion of the brainstem by inflammatory monocytes and neutrophils. In mice lacking I…

【数据结构与技术规格】

文件数 10 个，合计 10.75 MB。ppat.1006822.s001.tif：image/tiff，310.86 KB。ppat.1006822.s002.tif：image/tiff，382.79 KB。ppat.1006822.s003.tif：image/tiff，556.69 KB。数据集 DOI：10.1371/journal.ppat.1006822。

【主题与分类】

源站学科分类：Microbiology、Cell Biology、Neuroscience、Physiology、Ecology、Immunology。主题标签：WT、HSE、GKO mice、neutrophils、IFN、G-CSF-IFN、GM-CSF、IL -10 secretion、HSV 1 encephalitis、infection。

【适用方向】

源站学科分类标注为 Microbiology、Cell Biology、Neuroscience、Physiology、Ecology、Immunology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/IFN_inhibits_G-CSF_induced_neutrophil_expansion_and_invasion_of_the_CNS_to_prevent_viral_encephalitis/5806791

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Ramakrishna, Chandran; M. Cantin, Edouard (2018). IFNγ inhibits G-CSF induced neutrophil expansion and invasion of the CNS to prevent viral encephalitis. PLOS Pathogens. Dataset

【使用注意】

· 源站最后修改于 2023-05-31，引用时请注意版本时效。