多发性硬化症疾病成本系统综述

数据集获取（Figshare）

• 源站标题：Cost of Illness of Multiple Sclerosis - A Systematic Review
• DOI：10.1371/journal.pone.0159129
• 发布日期：2016-07-13
• 文件数：2 个
• 文件总体积：45.53 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Cost_of_Illness_of_Multiple_Sclerosis_-_A_Systematic_Review/3899676

命令行下载

curl -L -o "S1 Table.DOCX" "https://ndownloader.figshare.com/files/6108603"
curl -L -o "S2 Table.DOCX" "https://ndownloader.figshare.com/files/6108618"

文件清单

• S1 Table.DOCX（15.03 KB）
• S2 Table.DOCX（30.50 KB）

文件总体积 45.53 KB（源站 API 实测）。

数据说明

Background
Cost-of-illness (COI) studies of Multiple Sclerosis (MS) are vital components for describing the economic burden of MS, and are frequently used in model studies of interventions of MS. We conducted a systematic review of studies estimating the COI of MS, to compare costs between studies and examine cost drivers, emphasizing generalizability and methodological choices.
Material and method
A literature search on studies published in English on COI of MS was performed in PubMed for the period January 1969 to January 2014, resulting in 1,326 publications. A mapping of studies using a bottom-up approach or top-down approach, respectively, was conducted for the 48 studies assessed as relevant. In a second analysis, the cost estimates were compared between the 29 studies that used a societal perspective on costs, human capital approach for indirect costs, presenting number of patients included, time-period studied, and year of price level used.
Results
The mapping showed that bottom-up studies and prevalence approaches were most common. The cost ratios between different severity levels within studies were relatively stable, to the ratio of 1 to 2 to 3 for disability level categories. Drugs were the main cost drivers for MS-patients with low disease severity, representing 29% to 82% of all costs in this patient group, while the main cost components for groups with more advanced MS symptoms were production losses due to MS and informal care, together representing 17% to 67% of costs in those groups.
Conclusion
The bottom-up method and prevalence approach dominated in studies of COI of MS. Our findings show that there are difficulties in comparing absolute costs across studies, nevertheless, the relative costs expressed as cost ratios, comparing different severity levels, showed higher resemblance. Costs of drugs were main cost drivers for less severe MS and informal care and production losses for the most severe MS.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0159129（source: https://plos.figshare.com/articles/dataset/Cost_of_Illness_of_Multiple_Sclerosis_-_A_Systematic_Review/3899676）。