数据表1_一线利妥昔单抗后复发缓解型多发性硬化症治疗序列的成本效果：挪威微观模拟研究.docx

数据集获取（Figshare）

• 源站标题：Data Sheet 1_Cost-effectiveness of treatment sequences following first-line rituximab in relapsing-remitting multiple sclerosis: a Norwegian microsimulation study.docx
• DOI：10.3389/fneur.2026.1783506.s001
• 发布日期：2026-03-18
• 文件数：1 个
• 文件总体积：1.84 MB
• 源站页面：https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Cost-effectiveness_of_treatment_sequences_following_first-line_rituximab_in_relapsing-remitting_multiple_sclerosis_a_Norwegian_microsimulation_study_docx/31797979

命令行下载

curl -L -o "Data Sheet 1_Cost-effectiveness of treatment sequences following first-line rituximab in relapsing-remitting multiple sclerosis: a Norwegian microsimu.docx" "https://ndownloader.figshare.com/files/62908033"

文件清单

• Data Sheet 1_Cost-effectiveness of treatment sequences following first-line rituximab in relapsing-remitting multiple sclerosis: a Norwegian microsimu.docx（1.84 MB）

文件总体积 1.84 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

BackgroundThe Norwegian guideline recommends highly effective disease-modifying therapies (DMTs) as the first line treatment for multiple sclerosis (MS), with rituximab preferred in clinical practice. While rituximab is effective, patients may discontinue due to side-effects or develop disease activity. Limited guidance exists on optimal switches following first line rituximab.
ObjectivesTo estimate the costs and effects of different treatment sequences following first line rituximab in relapsing remitting MS patients in Norway.
DesignA microsimulation model adapted to the Norwegian setting estimated outcomes for different treatment sequences following first line rituximab. Four neurologists were interviewed using a structured expert elicitation tool to inform switching behavior. The model allowed for three treatment lines after rituximab, with switches possible to fingolimod, ponesimod, cladribine tablets, or natalizumab.
MethodsThe model simulated all 32 possible treatment sequences and calculated costs per quality adjusted life year (QALY) according to Norwegian pharmacoeconomic guidelines.
ResultsNeurologists were more likely to switch patients with >1 relapse (78%) or relapse and disability progression (66%) versus one relapse (54%). The most cost-effective sequence after rituximab is cladribine tablets (line 2), ponesimod (line 3), and natalizumab (line 4). The probability that second line cladribine tablets are most cost-effective is >75%. Mean time on first line rituximab was 15.2 years. The model predicts that over lifetime 21% of patients would require a fourth line of treatment due to the cumulative effects of discontinuation and recurring disease activity triggering treatment switches.
ConclusionPatients on first line rituximab may require a treatment switch due to side-effect induced discontinuation or new disease activity. If a switch from rituximab to another DMT is the preferred clinical course of action, this study showed that it is most cost-effective to switch to cladribine tablets followed by ponesimod and natalizumab.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.3389/fneur.2026.1783506.s001（source: https://frontiersin.figshare.com/articles/dataset/Data_Sheet_1_Cost-effectiveness_of_treatment_sequences_following_first-line_rituximab_in_relapsing-remitting_multiple_sclerosis_a_Norwegian_microsimulation_study_docx/31797979）。