隐球菌脑膜炎治疗策略在资源有限环境中的成本效果分析

数据集获取（Figshare）

• 源站标题：Cryptococcal Meningitis Treatment Strategies in Resource-Limited Settings: A Cost-Effectiveness Analysis
• DOI：10.1371/journal.pmed.1001316
• 发布日期：2012-09-25
• 文件数：10 个
• 文件总体积：2.28 MB
• 源站页面：https://plos.figshare.com/articles/dataset/Cryptococcal_Meningitis_Treatment_Strategies_in_Resource_Limited_Settings_A_Cost_Effectiveness_Analysis/119400

命令行下载

curl -L -o "Alternative_Language_Abstract_S1.docx" "https://ndownloader.figshare.com/files/301214"
curl -L -o "Alternative_Language_Abstract_S2.doc" "https://ndownloader.figshare.com/files/301224"
curl -L -o "Alternative_Language_Abstract_S3.doc" "https://ndownloader.figshare.com/files/301234"
curl -L -o "Alternative_Language_Abstract_S4.doc" "https://ndownloader.figshare.com/files/301246"
curl -L -o "Alternative_Language_Abstract_S5.doc" "https://ndownloader.figshare.com/files/301259"
curl -L -o "Figure_S1.tif" "https://ndownloader.figshare.com/files/301274"
curl -L -o "Figure_S2.tif" "https://ndownloader.figshare.com/files/301291"
curl -L -o "Table_S1.xlsx" "https://ndownloader.figshare.com/files/301306"

文件清单

• Alternative_Language_Abstract_S1.docx（16.72 KB）
• Alternative_Language_Abstract_S2.doc（31.23 KB）
• Alternative_Language_Abstract_S3.doc（28.67 KB）
• Alternative_Language_Abstract_S4.doc（33.79 KB）
• Alternative_Language_Abstract_S5.doc（27.65 KB）
• Figure_S1.tif（658.32 KB）
• Figure_S2.tif（1.41 MB）
• Table_S1.xlsx（13.35 KB）
• Table_S2.doc（30.72 KB）
• Table_S3.doc（31.23 KB）

文件总体积 2.28 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Cryptococcal meningitis (CM) is the most common form of meningitis in Africa. World Health Organization guidelines recommend 14-d amphotericin-based induction therapy; however, this is impractical for many resource-limited settings due to cost and intensive monitoring needs. A cost-effectiveness analysis was performed to guide stakeholders with respect to optimal CM treatment within resource limitations.
Methods and Findings:
We conducted a decision analysis to estimate the incremental cost-effectiveness ratio (ICER) of six CM induction regimens: fluconazole (800–1,200 mg/d) monotherapy, fluconazole + flucytosine (5FC), short-course amphotericin (7-d) + fluconazole, 14-d of amphotericin alone, amphotericin + fluconazole, and amphotericin + 5FC. We computed actual 2012 healthcare costs in Uganda for medications, supplies, and personnel, and average laboratory costs for three African countries. A systematic review of cryptococcal treatment trials in resource-limited areas summarized 10-wk survival outcomes. We modeled one-year survival based on South African, Ugandan, and Thai CM outcome data, and survival beyond one-year on Ugandan and Thai data. Quality-adjusted life years (QALYs) were determined and used to calculate the cost-effectiveness ratio and ICER. The cost of hospital care ranged from $154 for fluconazole monotherapy to $467 for 14 d of amphotericin + 5FC. Based on 18 studies investigating outcomes for HIV-infected individuals with CM in resource-limited settings, the estimated mean one-year survival was lowest for fluconazole monotherapy, at 40%. The cost-effectiveness ratio ranged from $20 to $44 per QALY. Overall, amphotericin-based regimens had higher costs but better survival. Short-course amphotericin (1 mg/kg/d for 7 d) with fluconazole (1,200 mg/d for14 d) had the best one-year survival (66%) and the most favorable cost-effectiveness ratio, at $20.24/QALY, with an ICER of $15.11 per additional QALY over fluconazole monotherapy. The main limitation of this study is the pooled nature of a systematic review, with a paucity of outcome data with direct comparisons between regimens.
Conclusions
Short-course (7-d) amphotericin induction th

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pmed.1001316（source: https://plos.figshare.com/articles/dataset/Cryptococcal_Meningitis_Treatment_Strategies_in_Resource_Limited_Settings_A_Cost_Effectiveness_Analysis/119400）。