干细胞衍生的脑样内皮细胞用于研究肺炎链球菌与脑内皮细胞的相互作用

资源简介

干细胞衍生的脑样内皮细胞用于研究肺炎链球菌与脑内皮细胞的相互作用

【数据集背景】

本数据集源站标题为《Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium》。配套论文《Stem cell-derived brain-like endothelial cells to interrogate

<i>Streptococcus pneumoniae</i>

interaction with brain endothelium》发表于 Virulence（2025），DOI：10.1080/21505594.2025.2564281。项目资助方：Funding for this research was provided by the National Institute of Neurological Orders and Stroke grant [R15NS131921] and the National Institute of Allergy and Infectious Diseases grant [R03AI185593]. J. Thornton’s lab was supported by the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH under Award Number [1R15AI142537] with co-funding from the National Institute of General Medical Sciences (NIGMS) Institutional Development Award (IDeA) Program. N. Vollmuth was supported by the Alexander von Humboldt Foundation (Alexander-von-Humboldt-Stiftung).。源站首次发布：2025-10-03。

【数据内容】

源站原始描述：Streptococcus pneumoniae (pneumococcus) is an opportunistic pathogen that remains the leading cause of bacterial meningitis worldwide. For meningitis to occur, pneumococcus must breach the blood-brain barrier (BBB), a highly specialized network of brain endothelial cells that comprise the microvasculature of the brain. Here, we report the use of human induced pluripotent stem cell-derived brain-like endothelial cells (iBECs) to model the BBB during pneumococcal infection. iBECs were infected wit…

【数据结构与技术规格】

文件数 6 个，合计 33.45 MB。数据集 DOI：10.6084/m9.figshare.30273826.v1。

【主题与分类】

源站学科分类：Medicine、Microbiology、Cell Biology、Neuroscience、Physiology、Immunology。主题标签：Streptococcus pneumoniae、blood-brain barrier、pneumococcal meningitis、brain endothelial cells、iPSC-BEC。

【适用方向】

源站学科分类标注为 Medicine、Microbiology、Cell Biology、Neuroscience、Physiology、Immunology。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/Stem_cell-derived_brain-like_endothelial_cells_to_interrogate_i_Streptococcus_pneumoniae_i_interaction_with_brain_endothelium/30273826

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Stem cell-derived brain-like endothelial cells to interrogate Streptococcus pneumoniae interaction with brain endothelium. Taylor &amp; Francis. Mauser, Henry D.; Keyzer, Taryn E.; Surma, Jessica M.; Alexander, Natalie G.; Cutts, William D.; Hathcock, Sarah F.; et al

【使用注意】

· 源站最后修改于 2026-01-21，引用时请注意版本时效。