新型JAK2抑制剂在真性红细胞增多症小鼠模型中的有效间歇给药研究数据集

资源简介

新型JAK2抑制剂在真性红细胞增多症小鼠模型中的有效间歇给药研究数据集

【数据集背景】

本数据集源站标题为《Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera》。配套论文《Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera》发表于 PLoS ONE（2012），DOI：10.1371/journal.pone.0037207。源站首次发布：2012-05-18。

【数据内容】

源站原始描述：A high percentage of patients with the myeloproliferative disorder polycythemia vera (PV) harbor a Val617→Phe activating mutation in the Janus kinase 2 (JAK2) gene, and both cell culture and mouse models have established a functional role for this mutation in the development of this disease. We describe the properties of MRLB-11055, a highly potent inhibitor of both the WT and V617F forms of JAK2, that has therapeutic efficacy in erythropoietin (EPO)-driven and JAK2V617F-driven mouse models of P…

【数据结构与技术规格】

文件数 7 个，合计 5.14 MB。Figure_S1.tif：image/tiff，591.33 KB。Figure_S2.tif：image/tiff，2.75 MB。Table_S1.doc：application/msword，37.38 KB。数据集 DOI：10.1371/journal.pone.0037207。

【主题与分类】

源站学科分类：Molecular Biology、Hematology、Pharmacology。主题标签：efficacious、intermittent、dosing、jak2、inhibitor、models、polycythemia、vera。

【适用方向】

源站学科分类标注为 Molecular Biology、Hematology、Pharmacology。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/Efficacious_Intermittent_Dosing_of_a_Novel_JAK2_Inhibitor_in_Mouse_Models_of_Polycythemia_Vera/124885

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Kraus, Manfred; Wang, Yuxun; Aleksandrowicz, Dan; Bachman, Eric; Szewczak, Alexander A.; Walker, Deborah; et al. (2016). Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-01，引用时请注意版本时效。