胸苷酸合成酶基因型指导的化疗用于胃癌和胃食管交界处癌症患者

数据集获取（Figshare）

• 源站标题：Thymidylate Synthase Genotype-Directed Chemotherapy for Patients with Gastric and Gastroesophageal Junction Cancers
• DOI：10.1371/journal.pone.0107424
• 发布日期：2014-09-18
• 文件数：3 个
• 文件总体积：1.07 MB
• 源站页面：https://plos.figshare.com/articles/dataset/_Thymidylate_Synthase_Genotype_Directed_Chemotherapy_for_Patients_with_Gastric_and_Gastroesophageal_Junction_Cancers_/1174158

命令行下载

curl -L -o "File_S1.docx" "https://ndownloader.figshare.com/files/1681458"
curl -L -o "Checklist_S1.pdf" "https://ndownloader.figshare.com/files/1681459"
curl -L -o "Protocol_S1.pdf" "https://ndownloader.figshare.com/files/1681460"

文件清单

• File_S1.docx（34.51 KB）
• Checklist_S1.pdf（371.06 KB）
• Protocol_S1.pdf（659.47 KB）

文件总体积 1.07 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Background
Retrospective studies indicate associations between TSER (thymidylate synthase enhancer region) genotypes and clinical outcomes in patients receiving 5-FU based chemotherapy, but well-controlled prospective validation has been lacking.
Methods
In this phase II study (NCT00515216 registered through ClinicalTrials.gov, http://clinicaltrials.gov/show/NCT00515216), patients with “good risk” TSER genotypes (at least one TSER2 allele) were treated with FOLFOX chemotherapy to determine whether prospective patient selection can improve overall response rates (ORR) in patients with gastric and gastroesophageal junction (GEJ) cancers, compared with historical outcomes in unselected patients (estimated 43%).
Results
The ORR in genotype-selected patients was 39.1% (9 partial responses out of 23 evaluable patients, 95% CI, 22.2 to 59.2), not achieving the primary objective of improving ORR. An encouraging disease control rate (DCR, consisting of partial responses and stable diseases) of 95.7% was noted and patients with homozygous TSER2 genotype showed better tumor response.
Conclusions
In this first prospective, multi-institutional study in patients with gastric or GEJ cancers, selecting patients with at least one TSER2 allele did not improve the ORR but led to an encouraging DCR. Further studies are needed to investigate the utility of selecting patients homozygous for the TSER2 allele and additional genomic markers in improving clinical outcomes for patients with gastric and GEJ cancers.
Trial Registration
ClinicalTrials.gov NCT00515216

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0107424（source: https://plos.figshare.com/articles/dataset/_Thymidylate_Synthase_Genotype_Directed_Chemotherapy_for_Patients_with_Gastric_and_Gastroesophageal_Junction_Cancers_/1174158）。