ITPA基因型与儿童急性淋巴细胞白血病维持治疗无事件生存及复发率关联数据集
308名儿童急性淋巴细胞白血病患者维持治疗中ITPA基因型与无事件生存和复发率关联的数据集。
基本信息
资源简介
ITPA基因型与儿童急性淋巴细胞白血病维持治疗无事件生存及复发率关联数据集
【数据集背景】
本数据集源站标题为《Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy》。配套论文《Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy》发表于 PLoS ONE（2014），DOI：10.1371/journal.pone.0109551。源站首次发布：2014-10-10。
【数据内容】
源站原始描述：Although the treatment of acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, failure due to treatment-related toxicities and relapse of the disease still occur in about 20% of patients. This retrospective study included 308 pediatric ALL patients undergoing maintenance therapy and investigated the effects of genetic variants of enzymes involved in the 6-mercaptopurine (6-MP) metabolism and folate pathway on survival and relapse rates. The presence of at least one…
【数据结构与技术规格】
文件数 2 个，合计 35.13 KB。Table_S1.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，14.78 KB。Table_S2.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，20.35 KB。数据集 DOI：10.1371/journal.pone.0109551。
【主题与分类】
源站学科分类：Biological Sciences。主题标签：retrospective study、therapy individualization、allele、survival、Lymphoblastic leukemia、ITPA Genotype、folate pathway、risk stratification、mp、ivs。
【适用方向】
组学数据适用于生物标志物发现与分子分型相关建模研究。
【获取与许可】
源站页面：https://plos.figshare.com/articles/dataset/_Association_of_ITPA_Genotype_with_Event_Free_Survival_and_Relapse_Rates_in_Children_with_Acute_Lymphoblastic_Leukemia_Undergoing_Maintenance_Therapy_/1200433
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Smid, Alenka; Karas-Kuzelicki, Natasa; Milek, Miha; Jazbec, Janez; Mlinaric-Rascan, Irena (2016). Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy. PLOS ONE. Dataset
【使用注意】
· 源站最后修改于 2023-06-02，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：Association of ITPA Genotype with Event-Free Survival and Relapse Rates in Children with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy
- DOI：10.1371/journal.pone.0109551
- 发布日期：2014-10-10
- 文件数：2 个
- 文件总体积：35.13 KB
- 源站页面：https://plos.figshare.com/articles/dataset/_Association_of_ITPA_Genotype_with_Event_Free_Survival_and_Relapse_Rates_in_Children_with_Acute_Lymphoblastic_Leukemia_Undergoing_Maintenance_Therapy_/1200433
命令行下载
curl -L -o "Table_S1.docx" "https://ndownloader.figshare.com/files/1713015"
curl -L -o "Table_S2.xlsx" "https://ndownloader.figshare.com/files/1713016"
文件清单
Table_S1.docx（14.78 KB）Table_S2.xlsx（20.35 KB）
文件总体积 35.13 KB（源站 API 实测）。
数据说明
Although the treatment of acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, failure due to treatment-related toxicities and relapse of the disease still occur in about 20% of patients. This retrospective study included 308 pediatric ALL patients undergoing maintenance therapy and investigated the effects of genetic variants of enzymes involved in the 6-mercaptopurine (6-MP) metabolism and folate pathway on survival and relapse rates. The presence of at least one of the non-functional ITPA alleles (94C>A and/or IVS2+21A>C variant) was associated with longer event-free survival compared to patients with the wild-type ITPA genotype (p = 0.033). Furthermore, patients carrying at least one non-functional ITPA allele were shown to be at a lower risk of suffering early (p = 0.003) and/or bone marrow relapse (p = 0.017). In conclusion, the ITPA genotype may serve as a genetic marker for the improvement of risk stratification and therapy individualization for patients with ALL.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.1371/journal.pone.0109551（source: https://plos.figshare.com/articles/dataset/_Association_of_ITPA_Genotype_with_Event_Free_Survival_and_Relapse_Rates_in_Children_with_Acute_Lymphoblastic_Leukemia_Undergoing_Maintenance_Therapy_/1200433）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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