晚期/转移性嗅神经母细胞瘤的综合分子谱数据集

数据集获取（Figshare）

• 源站标题：Comprehensive molecular profiling of advanced/metastatic olfactory neuroblastomas
• DOI：10.1371/journal.pone.0191244
• 发布日期：2018-01-11
• 文件数：5 个
• 文件总体积：123.41 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Comprehensive_molecular_profiling_of_advanced_metastatic_olfactory_neuroblastomas/5781771

命令行下载

curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/10201473"
curl -L -o "S2 Table.docx" "https://ndownloader.figshare.com/files/10201482"
curl -L -o "S1 Excel File.xlsx" "https://ndownloader.figshare.com/files/10201485"
curl -L -o "S2 Excel File.xlsx" "https://ndownloader.figshare.com/files/10201491"
curl -L -o "S3 Excel File.xlsx" "https://ndownloader.figshare.com/files/10201497"

文件清单

• S1 Table.docx（15.22 KB）
• S2 Table.docx（16.86 KB）
• S1 Excel File.xlsx（13.38 KB）
• S2 Excel File.xlsx（37.86 KB）
• S3 Excel File.xlsx（40.09 KB）

文件总体积 123.41 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Olfactory neuroblastoma (ONB) is a rare, locally aggressive, malignant neoplasm originating in the olfactory epithelium in the nasal vault. The recurrence rate of ONB remains high and there are no specific treatment guidelines for recurrent/metastatic ONBs. This study retrospectively evaluated 23 ONB samples profiled at Caris Life Sciences (Phoenix, Arizona) using DNA sequencing (Sanger/NGS [Illumina], n = 15) and gene fusions (Archer FusionPlex, n = 6), whole genome RNA microarray (HumanHT-12 v4 beadChip, Illumina, n = 4), gene copy number assays (chromogenic and fluorescent in situ hybridization), and immunohistochemistry. Mutations were detected in 63% ONBs including TP53, CTNNB1, EGFR, APC, cKIT, cMET, PDGFRA, CDH1, FH, and SMAD4 genes. Twenty-one genes were over-expressed and 19 genes under-expressed by microarray assay. Some of the upregulated genes included CD24, SCG2, and IGFBP-2. None of the cases harbored copy number variations of EGFR, HER2 and cMET genes, and no gene fusions were identified. Multiple protein biomarkers of potential response or resistance to classic chemotherapy drugs were identified, such as low ERCC1 [cisplatin sensitivity in 10/12], high TOPO1 [irinotecan sensitivity in 12/19], high TUBB3 [vincristine resistance in 13/14], and high MRP1 [multidrug resistance in 6/6 cases]. None of the cases (0/10) were positive for PD-L1 in tumor cells. Overexpression of pNTRK was observed in 67% (4/6) of the cases without underlying genetic alterations. Molecular alterations detected in our study (e.g., Wnt and cKIT/PDGFRA pathways) are potentially treatable using novel therapeutic approaches. Identified protein biomarkers of response or resistance to classic chemotherapy could be useful in optimizing existing chemotherapy treatment(s) in ONBs.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0191244（source: https://plos.figshare.com/articles/dataset/Comprehensive_molecular_profiling_of_advanced_metastatic_olfactory_neuroblastomas/5781771）。