镭-223和177Lu-PSMA-I&T治疗mCRPC的成本数据集

数据集获取（Figshare）

• 源站标题：Costs of radium-223 and the pharmacy preparation ¹⁷⁷Lu-PSMA-I&T for metastatic castration-resistant prostate cancer in Dutch hospitals
• DOI：10.6084/m9.figshare.22257156.v1
• 发布日期：2023-03-11
• 文件数：3 个
• 文件总体积：71.24 KB
• 源站页面：https://tandf.figshare.com/articles/dataset/Costs_of_radium-223_and_the_pharmacy_preparation_sup_177_sup_Lu-PSMA-I_T_for_metastatic_castration-resistant_prostate_cancer_in_Dutch_hospitals/22257156

命令行下载

curl -L -o "ijme_a_2183618_sm9618.docx" "https://ndownloader.figshare.com/files/39558657"
curl -L -o "ijme_a_2183618_sm9615.docx" "https://ndownloader.figshare.com/files/39558660"
curl -L -o "ijme_a_2183618_sm9612.docx" "https://ndownloader.figshare.com/files/39558663"

文件清单

• ijme_a_2183618_sm9618.docx（26.09 KB）
• ijme_a_2183618_sm9615.docx（27.80 KB）
• ijme_a_2183618_sm9612.docx（17.36 KB）

文件总体积 71.24 KB（源站 API 实测）。

数据说明

The radiopharmaceuticals radium-223 and the pharmacy preparation 177Lu-PSMA-I&T are reimbursed in the Netherlands for metastatic castration-resistant prostate cancer (mCRPC) treatment. Although shown to be life-prolonging in patients with mCRPC, the treatment procedures associated with these radiopharmaceuticals can be challenging for both patients and hospitals. This study investigates the costs of mCRPC treatment in Dutch hospitals for currently reimbursed radiopharmaceuticals with a demonstrated overall survival benefit.
A cost model that calculated the direct medical per-patient costs of radium-223 and 177Lu-PSMA-I&T was developed, following clinical trial regimens. The model considered six 4-weekly administrations (i.e. ALSYMPCA regimen) of radium-223. Regarding 177Lu-PSMA-I&T, the model used both the VISION regimen (i.e. five 6-weekly administrations) and the SPLASH regimen (i.e. four 8-weekly administrations). Based on health insurance claims, we also estimated the coverage a hospital would receive for providing treatment. No fitting health insurance claim for 177Lu-PSMA-I&T is currently available; therefore, we calculated a break-even value for a potential health insurance claim that would exactly counterbalance the per-patient costs and coverage.
Radium-223 administration is associated with per-patient costs of €30,905, and these costs are fully covered by the coverage a hospital receives. The per-patient costs of 177Lu-PSMA-I&T range between €35,866 and €47,546 per administration period, depending on the regimen. Current healthcare insurance claims do not fully cover the costs of providing 177Lu-PSMA-I&T: hospitals must pay €4,414–€4,922 for each patient out of their own budget. The break-even value for the potential insurance claim covering 177Lu-PSMA-I&T administration with a VISION (SPLASH) regimen is €1,073 (€1,215).
This study shows that, without consideration of the treatment effect, radium-223 treatment for mCRPC leads to lower per-patient costs than treatment with 177Lu-PSMA-I&T. The detailed overview of the costs associated with radiopharmaceutical treatment provided by this study is relevant for both hospitals and healthcare insurers.
Pro

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.6084/m9.figshare.22257156.v1（source: https://tandf.figshare.com/articles/dataset/Costs_of_radium-223_and_the_pharmacy_preparation_sup_177_sup_Lu-PSMA-I_T_for_metastatic_castration-resistant_prostate_cancer_in_Dutch_hospitals/22257156）。