骨髓源性生长因子调控的肺腺癌肿瘤发生与EGFR状态和癌症侵袭性相关的数据集

数据集获取（Figshare）

• 源站标题：Myeloid-Derived
  Growth Factor-Regulated Oncogenesis
  in Lung Adenocarcinoma Is Associated with EGFR Status and Cancer Aggressiveness
• DOI：10.1021/acs.jproteome.5c00385.s005
• 发布日期：2025-08-02
• 文件数：1 个
• 文件总体积：12.58 KB
• 源站页面：https://acs.figshare.com/articles/dataset/Myeloid-Derived_Growth_Factor-Regulated_Oncogenesis_in_Lung_Adenocarcinoma_Is_Associated_with_EGFR_Status_and_Cancer_Aggressiveness/29815310

命令行下载

curl -L -o "pr5c00385_si_005.xlsx" "https://ndownloader.figshare.com/files/56864891"

文件清单

• pr5c00385_si_005.xlsx（12.58 KB）

文件总体积 12.58 KB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Epidermal growth
factor receptor (EGFR) tyrosine kinase
inhibitors
have transformed lung adenocarcinoma (LUAD) treatment in EGFR-mutant
(MT) patients, but strategies targeting wild-type (WT) EGFR tumors
remain necessary. This study analyzed a diverse LUAD patient cohort
with EGFR mutation statuses and wild-type profiles for ALK and KRAS
to identify stage-specific biomarkers. Using quantitative proteomics
and multiomics, we discovered 21 dysregulated proteins in early-stage
EGFR-WT LUAD, identifying myeloid-derived growth factor (MYDGF) as
a key candidate biomarker. Elevated MYDGF levels in tissue (n = 117) and serum (n = 196) correlated
significantly with cancer stage in EGFR-WT patients but not EGFR-MT
cases. Notably, a higher tumor-to-normal MYDGF ratio predicted a favorable
prognosis in early-stage EGFR-WT LUAD. Functional studies demonstrated
that MYDGF exerts distinct roles in cell viability and migration depending
on its cellular localization and the invasive potential of cancer
cells. Specifically, secreted MYDGF promoted a protumorigenic phenotype,
whereas excess intracellular MYDGF appeared to suppress the oncogenic
capacity of aggressive cancer cells. MYDGF knockdown and subsequent
proteomic analysis provided further insights into these context-dependent
functions. These findings highlight EGFR status- and stage-specific
proteomic profiles in LUAD, emphasizing the importance of context-dependent
biomarker assessment for personalized treatment strategies.

许可

CC BY-NC 4.0

引用

学术使用请引用 DOI 10.1021/acs.jproteome.5c00385.s005（source: https://acs.figshare.com/articles/dataset/Myeloid-Derived_Growth_Factor-Regulated_Oncogenesis_in_Lung_Adenocarcinoma_Is_Associated_with_EGFR_Status_and_Cancer_Aggressiveness/29815310）。