PRJNA722927: Novel Cellular Patterns and Gene Drivers of Relapse in Adult Acute Myelogenous Leukemia
PRJNA722927: Novel Cellular Patterns and Gene Drivers of Relapse in Adult Acute Myelogenous Leukemia [Content] Through the analysis of 20 paired AML specimens procured before and at relapse from therapy we have identified three cellular relapse patterns: i) shift to immaturity; ii) proportional regrowth, and, iii) shift to monocyte-like cells. We traced AML driver mutations back into early HSC/MPP like cells. We identify high confidence genes that are differentially expressed in matched cell types between AML cells at diagnosis versus relapse. We credentialled a subset of these genes via CRISPR-Cas9 screens in ten AML cell lines. Overall, we identify novel patterns and drivers of AML relapse. [Topics] Tags: Transcriptome or Gene expression. [Access and licence] Source page: https://ncbi.nlm.nih.gov/bioproject/PRJNA722927
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PRJNA722927: Novel Cellular Patterns and Gene Drivers of Relapse in Adult Acute Myelogenous Leukemia
[Content]
Through the analysis of 20 paired AML specimens procured before and at relapse from therapy we have identified three cellular relapse patterns: i) shift to immaturity; ii) proportional regrowth, and, iii) shift to monocyte-like cells. We traced AML driver mutations back into early HSC/MPP like cells. We identify high confidence genes that are differentially expressed in matched cell types between AML cells at diagnosis versus relapse. We credentialled a subset of these genes via CRISPR-Cas9 screens in ten AML cell lines. Overall, we identify novel patterns and drivers of AML relapse.
[Topics]
Tags: Transcriptome or Gene expression.
[Access and licence]
Source page: https://ncbi.nlm.nih.gov/bioproject/PRJNA722927
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源站：https://ncbi.nlm.nih.gov/bioproject/PRJNA722927
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数据说明
通过对20对治疗前和复发时采集的配对AML标本进行分析，我们识别出三种细胞复发模式：i）向未成熟状态转变；ii）比例性再生长；iii）向单核细胞样细胞转变。我们将AML驱动突变追溯至早期HSC/MPP样细胞。我们鉴定出在诊断时与复发时的AML细胞之间，匹配细胞类型中差异表达的高置信度基因。我们通过CRISPR-Cas9筛选在十种AML细胞系中对其中一部分基因进行了验证。总体而言，我们识别出AML复发的新模式及驱动因素。
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