索拉非尼在肝细胞癌细胞中诱导的翻译重编程数据集

资源简介

索拉非尼在肝细胞癌细胞中诱导的翻译重编程数据集

【数据集背景】

本数据集源站标题为《Sorafenib-associated translation reprogramming in hepatocellular carcinoma cells》。配套论文《Sorafenib-associated translation reprogramming in hepatocellular carcinoma cells》发表于 RNA Biology（2025），DOI：10.1080/15476286.2025.2483484。项目资助方：This article is based upon work from COST action CA21154 TRANSLACORE supported by COST (European Cooperation in Science and Technology). Work in the laboratory of J.d.l.C. is supported by the project [R+D+i PID2022-136564NB-I00] funded by [MCIN/AEI/10.13039/501100011033] and ERDF/EU “A way of making Europe”. He also acknowledges the Andalusian Platform of Biomodels and Resources in Genomic Edition, and the FORTALECE Program (FORT23/00008) from MCIN.J.M. is supported by the Instituto de Salud Carlos III, ISCIII [PI16/00090 and PI19/01266], and the Consejería de Salud y Familias [PI-0216–2000] of the Andalusian Government. We also thank the Biomedical Research Network Center for Liver and Digestive Diseases (CIBEREHD) funded by ISCIII and co-financed by ERDF “A way to achieve Europe).L.C. was a recipient of an FPU contract from the Spanish Ministry [FPU16/05127]. A.R.-G. was funded by CIBERONC [CB16/12/00480] and the Andalusian Regional Government, University of Seville, and ERDF [US-1380874].。源站首次发布：2025-03-21。

【数据内容】

源站原始描述：Sorafenib (Sfb) is a multikinase inhibitor regularly used for the management of patients with advanced hepatocellular carcinoma (HCC) that has been shown to increase very modestly life expectancy. We have shown that Sfb inhibits protein synthesis at the level of initiation in cancer cells. However, the global snapshot of mRNA translation following Sorafenib-treatment has not been explored so far. In this study, we performed a genome-wide polysome profiling analysis in Sfb-treated HCC cells and d…

【数据结构与技术规格】

文件数 10 个，合计 15.72 MB。krnb_a_2483484_sm7087.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，23.49 KB。数据集 DOI：10.6084/m9.figshare.28638637.v1。

【主题与分类】

源站学科分类：Biochemistry、Cell Biology、Genetics、Molecular Biology、Pharmacology、Biological Sciences not elsewhere classified。主题标签：Hepatocellular carcinoma、polysome profiling、translation、m6A methylation、Sorafenib。

【适用方向】

源站学科分类标注为 Biochemistry、Cell Biology、Genetics、Molecular Biology、Pharmacology、Biological Sciences not elsewhere classified。

【获取与许可】

源站页面：https://tandf.figshare.com/articles/dataset/Sorafenib-associated_translation_reprogramming_in_hepatocellular_carcinoma_cells/28638637

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Sorafenib-associated translation reprogramming in hepatocellular carcinoma cells. Taylor & Francis. Contreras, Laura; Rodríguez-Gil, Alfonso; Muntané, Jordi; de la Cruz, Jesús

【使用注意】

· 源站最后修改于 2025-12-12，引用时请注意版本时效。