甲状腺癌的过度诊断与过度治疗：一项基于人群的时间趋势研究

数据集获取（Figshare）

• 源站标题：Overdiagnosis and overtreatment of thyroid cancer: A population-based temporal trend study
• DOI：10.1371/journal.pone.0179387
• 发布日期：2017-06-14
• 文件数：2 个
• 文件总体积：34.92 KB
• 源站页面：https://plos.figshare.com/articles/dataset/Overdiagnosis_and_overtreatment_of_thyroid_cancer_A_population-based_temporal_trend_study/5109127

命令行下载

curl -L -o "S1 Table.docx" "https://ndownloader.figshare.com/files/8677627"
curl -L -o "S2 Table.docx" "https://ndownloader.figshare.com/files/8677663"

文件清单

• S1 Table.docx（18.35 KB）
• S2 Table.docx（16.57 KB）

文件总体积 34.92 KB（源站 API 实测）。

数据说明

Background
The increase in incidence of thyroid cancer during the last decades without concomitant rise in mortality may reflect the growing detection of indolent forms of thyroid cancer, and may have fueled unnecessary thyroidectomies. Our aim was therefore, to compare recent secular trends in surgical intervention rate for thyroid cancer with the incidence and mortality of thyroid cancer to assess overdiagnosis and resulting overtreatment.
Methods
We conducted a population-based temporal trend study in Switzerland from 1998 to 2012. All cases of invasive thyroid cancer, deaths from thyroid cancer, and cancer-related thyroidectomies were analyzed. We calculated changes in age-standardized thyroid cancer incidence rates, stratified by histologic subtype and tumor stage, thyroid cancer-specific mortality, and thyroidectomy rates.
Results
Between 1998 and 2012, the age-standardized annual incidence of thyroid cancer increased from 5.9 to 11.7 cases/100,000 among women (annual mean absolute increase: +0.43/100,000/year) and from 2.7 to 3.9 cases/100,000 among men (+0.11/100,000/year). The increase was limited to the papillary subtype, the most indolent form of thyroid cancer. The incidence of early stages increased sharply, the incidence of advanced stages increased marginally, and the mortality from thyroid cancer decreased slightly. There was a three- to four-fold increase in the age-standardized annual thyroidectomy rate in both sexes.
Conclusions
We observed a large increase in the incidence of thyroid cancer, limited to papillary and early stage tumors, with a three- to four-fold parallel increase in thyroidectomy. The mortality slightly decreased. These findings suggest that a substantial and growing part of the detected thyroid cancers are overdiagnosed and overtreated.
Impact
Targeted screening and diagnostic strategies are warranted to avoid overdetection and unnecessary treatment of thyroid cancers.

许可

CC BY 4.0

引用

学术使用请引用 DOI 10.1371/journal.pone.0179387（source: https://plos.figshare.com/articles/dataset/Overdiagnosis_and_overtreatment_of_thyroid_cancer_A_population-based_temporal_trend_study/5109127）。