睾丸癌相关成纤维细胞的分子与表观遗传离体分析及其与生殖细胞肿瘤细胞和巨噬细胞的相互作用

资源简介

睾丸癌相关成纤维细胞的分子与表观遗传离体分析及其与生殖细胞肿瘤细胞和巨噬细胞的相互作用

【数据集背景】

本数据集源站标题为《Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages》。项目资助方：Wilhelm Sander-Stiftung。源站首次发布：2024-06-18。

【数据内容】

源站原始描述：Germ cell tumors (GCT) are the most common solid tumors in young men of age 15 - 40. In previous studies, we profiled the interaction of GCT cells with cells of the tumor microenvironment (TM), which showed that especially the 3D interaction of fibroblasts (FB) or macrophages with GCT cells influenced the growth behavior and cisplatin response as well as the transcriptome and secretome of the tumor cells, suggesting that the crosstalk of these cells with GCT cells is crucial for tumor progressio…

【数据结构与技术规格】

文件数 13 个，合计 23.46 MB。Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages.pdf：application/pdf，4.79 MB。Table S1.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，26.13 KB。Fig. 6.tiff：image/tiff，379.14 KB。数据集 DOI：10.6084/m9.figshare.26058097.v1。

【主题与分类】

源站学科分类：Cell development, proliferation and death、Cellular interactions (incl. adhesion, matrix, cell wall)、Proteomics and intermolecular interactions (excl. medical proteomics)、Signal transduction、Pathology (excl. oral pathology)、Cancer cell biology。主题标签：Germ cell tumors、Testis cancer、Cancer-associated fibroblasts、Fibroblasts、Macrophages、DNA methylation、Transcriptomics、Proteomics、Secretome、Biomarker。

【适用方向】

源站学科分类标注为 Cell development, proliferation and death、Cellular interactions (incl. adhesion, matrix, cell wall)、Proteomics and intermolecular interactions (excl. medical proteomics)、Signal transduction、Pathology (excl. oral pathology)、Cancer cell biology。

【获取与许可】

源站页面：https://figshare.com/articles/dataset/Molecular_and_epigenetic_i_ex_vivo_i_profiling_of_testis_cancer-associated_fibroblasts_and_their_interaction_with_germ_cell_tumor_cells_and_macrophages/26058097

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Nettersheim, Daniel (2024). Molecular and epigenetic ex vivo profiling of testis cancer-associated fibroblasts and their interaction with germ cell tumor cells and macrophages. figshare. Dataset

【使用注意】

· 源站最后修改于 2024-06-21，引用时请注意版本时效。