DNA结合剂对EWS-FLI1结合差异破坏的研究数据集

资源简介

DNA结合剂对EWS-FLI1结合差异破坏的研究数据集

【数据集背景】

本数据集源站标题为《Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents》。配套论文《Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents》发表于 PLoS ONE（2013），DOI：10.1371/journal.pone.0069714。源站首次发布：2013-07-22。

【数据内容】

源站原始描述：Fusion of the EWS gene to FLI1 produces a fusion oncoprotein that drives an aberrant gene expression program responsible for the development of Ewing sarcoma. We used a homogenous proximity assay to screen for compounds that disrupt the binding of EWS-FLI1 to its cognate DNA targets. A number of DNA-binding chemotherapeutic agents were found to non-specifically disrupt protein binding to DNA. In contrast, actinomycin D was found to preferentially disrupt EWS-FLI1 binding by comparison to p53 bin…

【数据结构与技术规格】

文件数 3 个，合计 854.65 KB。Figure_S1.tif：image/tiff，405.43 KB。Figure_S2.tif：image/tiff，402.63 KB。Table_S1.doc：application/msword，46.59 KB。数据集 DOI：10.1371/journal.pone.0069714。

【主题与分类】

源站学科分类：Medicine、Chemistry、Biological Sciences。主题标签：Biochemistry、proteins、DNA-binding proteins、chemical biology、drug discovery、Small molecules、biotechnology、organic chemistry、Organic compounds、Drugs and devices。

【适用方向】

源站学科分类标注为 Medicine、Chemistry、Biological Sciences。

【获取与许可】

源站页面：https://plos.figshare.com/articles/dataset/_Differential_Disruption_of_EWS_FLI1_Binding_by_DNA_Binding_Agents_/750008

使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。

规范引用：Chen, Changmin; R. Wonsey, Diane; E. Lemieux, Madeleine; L. Kung, Andrew (2016). Differential Disruption of EWS-FLI1 Binding by DNA-Binding Agents. PLOS ONE. Dataset

【使用注意】

· 源站最后修改于 2023-06-03，引用时请注意版本时效。