核壳结构多尺度磁性水凝胶机器人用于主动靶向递送

数据集获取（Figshare）

• 源站标题：Multiscale Magnetic
  Hydrogel Robot with a Core–Shell
  Structure for Active Targeted Delivery
• DOI：10.1021/acsapm.2c01555.s001
• 发布日期：2022-10-26
• 文件数：1 个
• 文件总体积：28.11 MB
• 源站页面：https://acs.figshare.com/articles/dataset/Multiscale_Magnetic_Hydrogel_Robot_with_a_Core_Shell_Structure_for_Active_Targeted_Delivery/21397822

命令行下载

curl -L -o "ap2c01555_si_001.zip" "https://ndownloader.figshare.com/files/37989598"

文件清单

• ap2c01555_si_001.zip（28.11 MB）

文件总体积 28.11 MB（源站 API 实测）。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Tremendous progress in applying small-scale
magnetic
robots for
targeted drug delivery has sparked a growing interest among researchers.
However, significant effort is needed to design and fabricate robots
to meet the needs of clinical treatments, such as biocompatibility,
biodegradation, and synergistic therapy. Here, we propose a multiscale
magnetic hydrogel robot (MMHR) with a core–shell structure
in which superparamagnetic nanoparticles and curcumin-loaded chitosan
microparticles (CCMs) are encapsulated inside the core, while doxorubicin-loaded
chitosan microparticles (DCMs) are embedded inside the shell. The
core and shell of the MMHR are composed of pH-sensitive calcium alginate
hydrogels that can alleviate the sudden release of drugs from CCMs
and DCMs in gastric fluid. MMHRs can be precisely actuated to the
target region through magnetic driving systems for further drug delivery.
The experimental results demonstrate that the MMHR possesses superior
obstacle-crossing ability and can successfully locomote on the surface
of the intestine. Additionally, the co-delivery of doxorubicin and
curcumin is realized through the different fabrication methods of
CCMs and DCMs and shows excellent synergistic therapeutic effects
against colon cancer cells. The powerful propulsion, good biocompatibility,
and remarkable synergistic efficacy of the MMHR offer a promising
route for active drug delivery through the gastrointestinal tract.

许可

CC BY-NC 4.0

引用

学术使用请引用 DOI 10.1021/acsapm.2c01555.s001（source: https://acs.figshare.com/articles/dataset/Multiscale_Magnetic_Hydrogel_Robot_with_a_Core_Shell_Structure_for_Active_Targeted_Delivery/21397822）。