中国南方患者膀胱尿路上皮癌深度基因组测序表1
中国南方膀胱尿路上皮癌患者的深度基因组测序数据集，包含22对肿瘤-正常样本的基因突变、拷贝数变异和肿瘤突变负荷信息。
基本信息
资源简介
中国南方患者膀胱尿路上皮癌深度基因组测序表1
【一句话概览】
本数据集是 figshare 公开的组学数据集，收录 1 个文件、合计 67.30 KB，主题涵盖 deep sequencing、genomic alteration、Chinese、bladder urothelial carcinoma、tumor mutation burden，可用于生物标志物发现与分子分型研究，CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx》。配套论文《Novel therapeutic targets in advanced urothelial carcinoma》发表于 Critical Reviews in Oncology/Hematology（2016），DOI：10.1016/j.critrevonc.2015.10.021。源站首次发布：2021-05-14。
【数据内容】
源站原始描述：ObjectiveBladder urothelial carcinoma (BUC) is a common urological malignancy with molecular heterogeneity. However, the genetic feature of Chinese BUC patients is still not well-identified. MethodsWe performed deep sequencing by a large panel (450 genes) on 22 BUC samples and using matched normal bladder tissue as control. Genomic alterations (GAs), pathways and Tumor Mutation Burden (TMB) were investigated. ResultsThe frequencies of GAs (TERT, 54.5%; CREBBP, 27.3%; GATA3, 22.7%; BRAF, 18.2%; T…
中文译文（机器翻译，仅供快速理解，请以原文为准）：目的 膀胱尿路上皮癌（BUC）是一种常见的泌尿系统恶性肿瘤，具有分子异质性。然而，中国BUC患者的基因特征仍未得到充分明确。 方法 我们使用一个大型panel（450个基因）对22例BUC样本进行深度测序，并以配对的正常膀胱组织作为对照。分析了基因组改变（GAs）、通路和肿瘤突变负荷（TMB）。 结果 GAs的频率（TERT，54.5%；CREBBP，27.3%；GATA3，22.7%；BRAF，18.2%；TEK，18.2%；GLI1，18.2%）在中国BUC患者中显著高于西方BUC患者。其他GAs的频率与既往研究一致（TP53，50.0%；KDM6A，31.8%；KMT2D，22.7%等）。此外
【数据结构与技术规格】
文件数 1 个，合计 67.30 KB。Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx：application/vnd.openxmlformats-officedocument.spreadsheetml.sheet，67.30 KB。数据集 DOI：10.3389/fonc.2021.538927.s001。
【主题与分类】
源站学科分类：Cancer、Haematological Tumours、Radiation Therapy、Solid Tumours、Oncology and Carcinogenesis not elsewhere classified、Molecular Targets。主题标签：deep sequencing、genomic alteration、Chinese、bladder urothelial carcinoma、tumor mutation burden。
【适用方向】
组学数据适用于生物标志物发现与分子分型相关建模研究。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_Deep_Genomic_Sequencing_of_Bladder_Urothelial_Carcinoma_in_Southern_Chinese_Patients_A_Single-Center_Study_xlsx/14594940
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Li, Dong-Yang; Yang, Fei; Liao, Wei-Qiang; Zhou, Xiang-Fu; Li, Wen-Biao; Cai, Jia-Rong; et al. (2021). Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx. Frontiers. Dataset
【使用注意】
· 源站最后修改于 2023-06-04，引用时请注意版本时效。
下载信息
注册下载
需要注册 Kaggle 账号并登录后下载，适合需要跟踪下载记录和使用 API 的用户。
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无需注册即可直接获取公开样本或文档，适合快速预览和评估数据集质量。
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公开数据集受托下载与技术交付服务。
提供高速下载与技术交付服务（收技术服务费，非数据销售）
暂未开放当前数据集主要来源为 Kaggle 公开托管，完整影像包建议通过原始链接或 Kaggle API 获取。
使用方式
数据集获取（Figshare）
- 源站标题：Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx
- DOI：10.3389/fonc.2021.538927.s001
- 发布日期：2021-05-14
- 文件数：1 个
- 文件总体积：67.30 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/Table_1_Deep_Genomic_Sequencing_of_Bladder_Urothelial_Carcinoma_in_Southern_Chinese_Patients_A_Single-Center_Study_xlsx/14594940
命令行下载
curl -L -o "Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx" "https://ndownloader.figshare.com/files/28007193"
文件清单
Table_1_Deep Genomic Sequencing of Bladder Urothelial Carcinoma in Southern Chinese Patients: A Single-Center Study.xlsx（67.30 KB）
文件总体积 67.30 KB（源站 API 实测）。
数据加载示例（图像类）
from PIL import Image
import glob, os
files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
+ glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)
# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path) # 要求 子目录=类别
目录组织与标注格式以源站说明和下载后实际文件为准。
数据说明
ObjectiveBladder urothelial carcinoma (BUC) is a common urological malignancy with molecular heterogeneity. However, the genetic feature of Chinese BUC patients is still not well-identified.
MethodsWe performed deep sequencing by a large panel (450 genes) on 22 BUC samples and using matched normal bladder tissue as control. Genomic alterations (GAs), pathways and Tumor Mutation Burden (TMB) were investigated.
ResultsThe frequencies of GAs (TERT, 54.5%; CREBBP, 27.3%; GATA3, 22.7%; BRAF, 18.2%; TEK, 18.2% and GLI1, 18.2%) were significantly higher in Chinese than Western BUC patients. Other GAs’ frequencies were in accordance with previous study (TP53, 50.0%; KDM6A, 31.8%; KMT2D, 22.7%; etc.). Besides, we detected gene amplification in ERBB2, FRS2, FAS, etc. The gene fusion/rearrangement took place in the chromosome 11, 12, 14, 17, 19, 22, and Y. Other than cell cycle and PI3K-AKT-mTOR, mutated genes were more associated with the transcription factor, chromatin modification signaling pathways. Interestingly, the TMB value was significantly higher in the BUC patients at stages T1–T2 than T3–T4 (P = 0.025).
ConclusionDeep genomic sequencing of BUC can provide new clues on the unique GAs of Chinese patients and assist in therapeutic decision.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fonc.2021.538927.s001（source: https://frontiersin.figshare.com/articles/dataset/Table_1_Deep_Genomic_Sequencing_of_Bladder_Urothelial_Carcinoma_in_Southern_Chinese_Patients_A_Single-Center_Study_xlsx/14594940）。
数据缺失？
依托陕西、四川两大基地，我们与超过十家三甲医院建立直接合作关系，覆盖合规授权、采集治理、专业标注、数据交付的全流程，为AI医疗团队提供即拿即用的高质量临床数据。
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