DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia
急性髓系白血病铜死亡相关lncRNA预后签名的补充数据表。
基本信息
资源简介
DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia
【一句话概览】
本数据集是 figshare 公开的文本数据集，收录 1 个文件、合计 759.70 KB，主题涵盖 cuproptosis-related Genes (CRGs)、long non-coding RNAs (lncRNAs)、acute myeloid leukemia (AML)、prognostic value、chemotherapy and immunotherapy，可用于医学自然语言处理（实体识别、信息抽取等），CC BY 4.0 许可开放获取。
【数据集背景】
本数据集源站标题为《DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx》。配套论文《Identification of seven novel ferroptosis-related long non-coding RNA signatures as a diagnostic biomarker for acute myeloid leukemia》发表于 BMC Medical Genomics（2021），DOI：10.1186/s12920-021-01085-9。源站首次发布：2022-10-07。
【数据内容】
源站原始描述：BackgroundCuproptosis is a type of programmed cell death that is involved in multiple physiological and pathological processes, including cancer. We constructed a prognostic cuproptosis-related long non-coding RNA (lncRNA) signature for acute myeloid leukemia (AML). MethodsRNA-seq and clinical data for AML patients were acquired from The Cancer Genome Atlas (TCGA) database. The cuproptosis-related prognostic lncRNAs were identified by co-expression and univariate Cox regression analysis. The lea…
【数据结构与技术规格】
文件数 1 个，合计 759.70 KB。DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx：application/vnd.openxmlformats-officedocument.wordprocessingml.document，759.70 KB。数据集 DOI：10.3389/fonc.2022.966920.s001。
【主题与分类】
源站学科分类：Cancer、Haematological Tumours、Molecular Targets、Radiation Therapy、Oncology and Carcinogenesis not elsewhere classified、Solid Tumours。主题标签：cuproptosis-related Genes (CRGs)、long non-coding RNAs (lncRNAs)、acute myeloid leukemia (AML)、prognostic value、chemotherapy and immunotherapy。
【适用方向】
文本类数据可用于医学自然语言处理，如命名实体识别、信息抽取与文本分类。
【获取与许可】
源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_1_A_novel_cuproptosis-related_LncRNA_signature_Prognostic_and_therapeutic_value_for_acute_myeloid_leukemia_docx/21292782
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：Li, Pian; Li, Junjun; Wen, Feng; Cao, Yixiong; Luo, Zeyu; Zuo, Juan; et al. (2022). DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx. Frontiers. Dataset
【使用注意】
· 源站最后修改于 2023-06-13，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx
- DOI：10.3389/fonc.2022.966920.s001
- 发布日期：2022-10-07
- 文件数：1 个
- 文件总体积：759.70 KB
- 源站页面：https://frontiersin.figshare.com/articles/dataset/DataSheet_1_A_novel_cuproptosis-related_LncRNA_signature_Prognostic_and_therapeutic_value_for_acute_myeloid_leukemia_docx/21292782
命令行下载
curl -L -o "DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx" "https://ndownloader.figshare.com/files/37776591"
文件清单
DataSheet_1_A novel cuproptosis-related LncRNA signature: Prognostic and therapeutic value for acute myeloid leukemia.docx（759.70 KB）
文件总体积 759.70 KB（源站 API 实测）。
数据说明
BackgroundCuproptosis is a type of programmed cell death that is involved in multiple physiological and pathological processes, including cancer. We constructed a prognostic cuproptosis-related long non-coding RNA (lncRNA) signature for acute myeloid leukemia (AML).
MethodsRNA-seq and clinical data for AML patients were acquired from The Cancer Genome Atlas (TCGA) database. The cuproptosis-related prognostic lncRNAs were identified by co-expression and univariate Cox regression analysis. The least absolute shrinkage and selection operator (LASSO) was performed to construct a cuproptosis-related lncRNA signature, after which the AML patients were classified into two risk groups based on the risk model. Kaplan-Meier, ROC, univariate and multivariate Cox regression, nomogram, and calibration curves analyses were used to evaluate the prognostic value of the model. Then, expression levels of the lncRNAs in the signature were investigated in AML samples by quantitative polymerase chain reaction (qPCR). KEGG functional analysis, single-sample GSEA (ssGSEA), and the ESTIMATE algorithm were used to analyze the mechanisms and immune status between the different risk groups. The sensitivities for potential therapeutic drugs for AML were also investigated.
ResultsFive hundred and three lncRNAs related to 19 CRGs in AML samples from the TCGA database were obtained, and 21 differentially expressed lncRNAs were identified based on the 2-year overall survival (OS) outcomes of AML patients. A 4-cuproptosis-related lncRNA signature for survival was constructed by LASSO Cox regression. High-risk AML patients exhibited worse outcomes. Univariate and multivariate Cox regression analyses demonstrated the independent prognostic value of the model. ROC, nomogram, and calibration curves analyses revealed the predictive power of the signature. KEGG pathway and ssGSEA analyses showed that the high-risk group had higher immune activities. Lastly, AML patients from different risk groups showed differential responses to various agents.
ConclusionA cuproptosis-related lncRNA signature was established to predict the prognosis and inform on potential therapeutic strategies for AML patients.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.3389/fonc.2022.966920.s001（source: https://frontiersin.figshare.com/articles/dataset/DataSheet_1_A_novel_cuproptosis-related_LncRNA_signature_Prognostic_and_therapeutic_value_for_acute_myeloid_leukemia_docx/21292782）。
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