数据来自：复发性急性髓系白血病的基因组特征揭示新的潜在治疗靶点

数据集获取（Figshare）

• 源站标题：Data from: Genomic characterization of relapsed acute myeloid leukemia reveals novel putative therapeutic targets
• DOI：10.17044/scilifelab.12292778.v1
• 发布日期：2021-02-11
• 源站页面：https://figshare.scilifelab.se/articles/dataset/Data_from_Genomic_characterization_of_relapsed_acute_myeloid_leukemia_reveals_novel_putative_therapeutic_targets/12292778

源站：https://figshare.com/articles/dataset/Data_from_Genomic_characterization_of_relapsed_acute_myeloid_leukemia_reveals_novel_putative_therapeutic_targets/12292778

按页面 Download 按钮获取。

数据加载示例（图像类）

from PIL import Image
import glob, os

files = (glob.glob(os.path.join(path, "**", "*.png"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.jpg"), recursive=True)
       + glob.glob(os.path.join(path, "**", "*.tif"), recursive=True))
print("图像文件数:", len(files))
img = Image.open(files[0]); print("尺寸/模式:", img.size, img.mode)

# torchvision Dataset 方式:
# from torchvision import datasets
# ds = datasets.ImageFolder(path)  # 要求 子目录=类别

目录组织与标注格式以源站说明和下载后实际文件为准。

数据说明

Data Set Description

These data are collected from a total of 73 participants (48 adult; 25 pediatric), all of which had relapsed or primary resistant acute myeloid leukemia. The data, which here are separated into an adult and a pediatric dataset, were generated as part of a study by Stratmann et. al., 2021 (https://doi.org/10.1182/bloodadvances.2020003709).

Please note that separate applications are necessary for the adult and pediatric dataset, respectively. When applying for access, please indicate which of the datasets that the application applies for.

The adult dataset contains whole genome sequencing data from 62 diagnosis (D), relapse (R1/R2/R3) and/or primary resistant (PR) leukemia samples, and 37 normal (G) DNA samples from 37 patients, as well as whole exome sequencing data from 20 leukemia samples and one (1) normal DNA sample from 15 patients.

The pediatric dataset contains whole genome sequencing data from 49 diagnosis (D), relapse (R1/R2/R3), persistent relapse (R1/2-P) and/or primary resistant (PR) leukemia samples and 24 normal (G) DNA samples from 23 patients, as well as whole exome sequencing data from seven (7) leukemia samples from five (5) patients.

The leukemia samples originate from bone marrow or peripheral blood. The patient-matched normal DNA samples originate from either complete remission bone marrow or peripheral blood cells, or from normal bone marrow stromal cells cultivated from leukemia bone marrow. Further details regarding the samples are available in the Supplemental Information part of Stratmann et. al., 2021 (https://doi.org/10.1182/bloodadvances.2020003709).

Whole genome sequencing libraries and associated next-generation sequencing were carried out by the SNP&SEQ Technology platform, SciLifeLab, National Genomics Infrastructure Uppsala, Sweden. Libraries were prepared using the TruSeq PCR-free DNA sample preparation Kit, followed by paired-end 150bp read length sequencing on a HiSeqX (Illumina Inc.).

Whole exome sequencing libraries and associated next-generation sequencing were carried out by the Uppsala Genome Center, SciLifeLab, National Genomics Infrastructure Uppsala, Sweden. Libraries were performed using th

许可

Restricted Access

引用

学术使用请引用 DOI 10.17044/scilifelab.12292778.v1（source: https://figshare.scilifelab.se/articles/dataset/Data_from_Genomic_characterization_of_relapsed_acute_myeloid_leukemia_reveals_novel_putative_therapeutic_targets/12292778）。