IFN-Lambda3和IFN-Lambda4基因分型在慢性丙型肝炎基因型2/3患者中的表现和价值
慢性丙型肝炎基因型2/3患者的IFN-Lambda3和IFN-Lambda4基因分型数据及治疗反应分析。
基本信息
资源简介
IFN-Lambda3和IFN-Lambda4基因分型在慢性丙型肝炎基因型2/3患者中的表现和价值
【数据集背景】
本数据集源站标题为《Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting》。配套论文《Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting》发表于 PLOS ONE（2015），DOI：10.1371/journal.pone.0145622。源站首次发布：2016-01-05。
【数据内容】
源站原始描述：Background SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3. Methods We recruited 1006 patients with c…
文件 S1_Fig.eps 为文本内容，开头为：%!PS-Adobe-3.0 EPSF-3.0 %APL_DSC_Encoding: UTF8 %APLProducer: (Version 10.10.5 (Build 14F1021) Quartz PS Context) %%Title: (Unknown) %%Creator: (Unknown) %%Cre…
【数据结构与技术规格】
文件数 4 个，合计 1.30 MB。S1_Data.xls：application/vnd.ms-excel，1.04 MB。S1_Fig.eps：application/postscript，159.79 KB。S1_Table.doc：application/msword，78.85 KB。数据集 DOI：10.1371/journal.pone.0145622。
【主题与分类】
源站学科分类：Biological Sciences。主题标签：3 gene、svr、rvr、serum samples、infl、dinucleotide frame shift、IFNL 4.、1006 patients、EDTA blood samples、hepatitis C genotype。
【适用方向】
结构化表格数据可直接用于统计建模、特征工程与队列分析。
【获取与许可】
源站页面：https://plos.figshare.com/articles/dataset/_Performance_and_Value_of_IFN_Lambda3_and_IFN_Lambda4_Genotyping_in_Patients_with_Chronic_Hepatitis_C_CHC_Genotype_2_3_in_a_Real_World_Setting_/1628322
使用许可：CC BY 4.0（https://creativecommons.org/licenses/by/4.0/）。
规范引用：B. Wiegand, Steffen; Heidrich, Benjamin; Susser, Simone; Rogalska-Taranta, Magdalena; Petersen, Jörg; H. W. Böker, Klaus; et al. (2016). Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting. PLOS ONE. Dataset
【使用注意】
· 源站最后修改于 2023-06-03，引用时请注意版本时效。
下载信息
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使用方式
数据集获取（Figshare）
- 源站标题：Performance and Value of IFN-Lambda3 and IFN-Lambda4 Genotyping in Patients with Chronic Hepatitis C (CHC) Genotype 2/3 in a Real World Setting
- DOI：10.1371/journal.pone.0145622
- 发布日期：2016-01-05
- 文件数：4 个
- 文件总体积：1.30 MB
- 源站页面：https://plos.figshare.com/articles/dataset/_Performance_and_Value_of_IFN_Lambda3_and_IFN_Lambda4_Genotyping_in_Patients_with_Chronic_Hepatitis_C_CHC_Genotype_2_3_in_a_Real_World_Setting_/1628322
命令行下载
curl -L -o "S1_Data.xls" "https://ndownloader.figshare.com/files/2613901"
curl -L -o "S1_Fig.eps" "https://ndownloader.figshare.com/files/2613902"
curl -L -o "S1_Table.doc" "https://ndownloader.figshare.com/files/2613903"
curl -L -o "S1_Text.docx" "https://ndownloader.figshare.com/files/2613904"
文件清单
S1_Data.xls（1.04 MB）S1_Fig.eps（159.79 KB）S1_Table.doc（78.85 KB）S1_Text.docx（19.56 KB）
文件总体积 1.30 MB（源站 API 实测）。
数据说明
Background
SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. In this study, we compared the role of IFNL4 variants with IFNL3-(rs12979860) and IFNL3-(rs8099917) on response to pegylated (PEG)-IFN and Ribavirin (RBV) in patients with chronic hepatitis C GT2/3.
Methods
We recruited 1006 patients with chronic hepatitis C and GT2/3 in a large German registry. A treatment with PEG-IFN and Ribavirin was started by 959 patients. We performed genotyping of IFNL3 (rs12979860, n = 726; rs8099917, n = 687) and of IFNL4 (ss469415590; n = 631).
Results
Both preferable IFNL3 genotypes were associated with RVR (both pConclusion
IFNL3 genotyping from serum was highly efficient and can be used as an alternative if EDTA whole blood is not available. In Caucasian GT2/3 patients genotyping for INFL4-(ss469415590) does not lead to additional information for the decision-making process. Importantly, IFNL3 SNPs were not associated with SVR but with RVR. Even in the era of new direct acting antiviral (DAA) therapies, IFNL3 testing may therefore still be considered for naïve GT2/3 patients to decide if dual Peg-IFN/RBV therapy is an option in resource limited regions.
许可
CC BY 4.0
引用
学术使用请引用 DOI 10.1371/journal.pone.0145622（source: https://plos.figshare.com/articles/dataset/_Performance_and_Value_of_IFN_Lambda3_and_IFN_Lambda4_Genotyping_in_Patients_with_Chronic_Hepatitis_C_CHC_Genotype_2_3_in_a_Real_World_Setting_/1628322）。
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